SK-N-BE(2)人神经母细胞瘤细胞

SK-N-BE(2)/SK-N-BE(2)细胞系/SK-N-BE(2)细胞株/SK-N-BE(2)人神经母细胞瘤细胞

Cell line name SK-N-BE(2)

Synonyms SK-N-BE2; SK-N-BE-2; SKNBE(2); SKNBE-2; SKNBE2; SK-N-BE; SKNBE

Accession CVCL_0528

Resource Identification Initiative To cite this cell line use: SK-N-BE(2) (RRID:CVCL_0528)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

From: Memorial Sloan Kettering Cancer Center; New York; USA.

Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK1980-530.

Population: Caucasian.

Characteristics: Substrate-adherent type (S-type) (PubMed=15720811).

Doubling time: 27 hours (PubMed=29704); ~36 hours (DSMZ=ACC-632).

Omics: Array-based CGH.

Omics: Deep exome analysis.

Omics: Deep quantitative phosphoproteome analysis.

Omics: Deep tyrosine phosphoproteome analysis.

Omics: DNA methylation analysis.

Omics: Metabolome analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.

DOI=10.1016/B978-0-12-333530-2.50006-X

Israel M.A., Thiele C.J.

Tumor cell lines of the peripheral nervous system.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York; USA (1994)

 

PubMed=7838528

Cheng N.C., Van Roy N., Chan A., Beitsma M., Westerveld A., Speleman F., Versteeg R.

Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.

Oncogene 10:291-297(1995)

 

DOI=10.1007/0-306-46872-7_2

Thiele C.J.

Neuroblastoma.

(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999)

 

PubMed=11507071

Keshelava N., Zuo J.J., Chen P., Waidyaratne S.N., Luna M.C., Gomer C.J., Triche T.J., Reynolds C.P.

Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines.

Cancer Res. 61:6185-6193(2001)

 

PubMed=11550280; DOI=10.1002/gcc.1174

Van Roy N., Van Limbergen H., Vandesompele J., Van Gele M., Poppe B., Salwen H.R., Laureys G., Manoel N., De Paepe A., Speleman F.

Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.

Genes Chromosomes Cancer 32:126-135(2001)

 

PubMed=15720811; DOI=10.1593/neo.04310; PMCID=PMC1531688

Walton J.D., Kattan D.R., Thomas S.K., Spengler B.A., Guo H.-F., Biedler J.L., Cheung N.-K.V., Ross R.A.

Characteristics of stem cells from human neuroblastoma cell lines and in tumors.

Neoplasia 6:838-845(2004)

 

PubMed=15892104; DOI=10.1002/gcc.20198

Mosse Y.P., Greshock J., Margolin A.A., Naylor T., Cole K.A., Khazi D., Hii G., Winter C., Shahzad S., Asziz M.U., Biegel J.A., Weber B.L., Maris J.M.

High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.

Genes Chromosomes Cancer 43:390-403(2005)

 

PubMed=16822308; DOI=10.1186/1471-2407-6-177; PMCID=PMC1533846

Dam V., Morgan B.T., Mazanek P., Hogarty M.D.

Mutations in PIK3CA are infrequent in neuroblastoma.

BMC Cancer 6:177.1-177.10(2006)

 

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)

 

PubMed=20631050; DOI=10.1101/gr.106252.110; PMCID=PMC2928498

Storlazzi C.T., Lonoce A., Guastadisegni M.C., Trombetta D., D'Addabbo P., Daniele G., L'Abbate A., Macchia G., Surace C., Kok K., Ullmann R., Purgato S., Palumbo O., Carella M., Ambros P.F., Rocchi M.

Gene amplification as double minutes or homogeneously staining regions in solid tumors: origin and structure.

Genome Res. 20:1198-1206(2010)

 

PubMed=20655465; DOI=10.1016/j.cell.2010.06.004; PMCID=PMC2913027

Holzel M., Huang S.-D., Koster J., Ora I., Lakeman A., Caron H.N., Nijkamp W., Xie J., Callens T., Asgharzadeh S., Seeger R.C., Messiaen L.M., Versteeg R., Bernards R.

NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.

Cell 142:218-229(2010)