HCC95细胞

HCC95/HCC95细胞系/HCC95细胞株/HCC95人肺腺癌细胞

Cell line name HCC95

Synonyms HCC-95; HCC0095; Hamon Cancer Center 95

Accession CVCL_5137

Resource Identification Initiative To cite this cell line use: HCC95 (RRID:CVCL_5137)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: MD Anderson Cell Lines Project.

Part of: TCGA-110-CL cell line panel.

Population: Caucasian.

Doubling time: 40.6 hours (PubMed=29681454).

Omics: Array-based CGH.

Omics: Deep exome analysis.

Omics: Deep proteome analysis.

Omics: Deep quantitative proteome analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Miscellaneous: Direct author submission of STR profile from Girard, Luc and Gazdar, Adi F.

Caution: Indicated as originating from a 65 year old male patient in PubMed=10353731 and from a 70 year old in PubMed=9559342.

Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.

Sequence variations

Mutation; HGNC; 11998; TP53; Simple; p.Arg335Valfs*10 (c.1002delG) (p.Gly334fs); Zygosity=Homozygous (PubMed=20557307; DepMap=ACH-000454).

HLA typing Source: PubMed=26589293

Class I

HLA-A A*11:01,29:02

HLA-B B*13:02,18:01

HLA-C C*16:01,16:01

Genome ancestry Source: PubMed=30894373

 

Origin % genome

African 0.18

Native American 0.36

East Asian, North 1.64

East Asian, South 0

South Asian 2.05

European, North 62.63

European, South 33.13

Disease Lung squamous cell carcinoma (NCIt: C3493)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual CVCL_S841 ! HCC95 BL

Sex of cell Male

Age at sampling 65Y

Category Cancer cell line

STR profile Source(s): Direct_author_submission; KCLB=70095; PubMed=20679594; PubMed=25877200

 

Markers:

Amelogenin X

CSF1PO 10,12 (Direct_author_submission; PubMed=20679594; PubMed=25877200)

12 (KCLB=70095)

D1S1656 17.3

D2S441 10,14

D2S1338 23

D3S1358 17

D5S818 10,11 (KCLB=70095)

11 (Direct_author_submission; PubMed=20679594)

11,12 (PubMed=25877200)

D7S820 10

D8S1179 14,16

D10S1248 13,14

D12S391 17,22

D13S317 11 (KCLB=70095; PubMed=20679594)

11,12 (Direct_author_submission; PubMed=25877200)

D16S539 9

D18S51 16,20

D19S433 15,16

D21S11 29,30

D22S1045 16

FGA 22

Penta D 9

Penta E 12,17

TH01 8,9

TPOX 8,11

vWA 14,17

 

Run an STR similarity search on this cell line

PubMed=9559342; DOI=10.1002/(SICI)1098-2264(199804)21:4<308::AID-GCC4>3.0.CO;2-2

Virmani A.K., Fong K.M., Kodagoda D.R., McIntire D., Hung J.Y., Tonk V., Minna J.D., Gazdar A.F.

Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types.

Genes Chromosomes Cancer 21:308-319(1998)

 

PubMed=10353731

Wistuba I.I., Bryant D., Behrens C., Milchgrub S., Virmani A.K., Ashfaq R., Minna J.D., Gazdar A.F.

Comparison of features of human lung cancer cell lines and their corresponding tumors.

Clin. Cancer Res. 5:991-1000(1999)

 

PubMed=10987304

Girard L., Zochbauer-Muller S., Virmani A.K., Gazdar A.F., Minna J.D.

Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.

Cancer Res. 60:4894-4906(2000)

 

PubMed=16187286; DOI=10.1002/ijc.21491

Garnis C., Lockwood W.W., Vucic E., Ge Y., Girard L., Minna J.D., Gazdar A.F., Lam S., MacAulay C., Lam W.L.

High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH.

Int. J. Cancer 118:1556-1564(2006)

 

PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846

Blanco R., Iwakawa R., Tang M.-Y., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.

A gene-alteration profile of human lung cancer cell lines.

Hum. Mutat. 30:1199-1206(2009)

 

PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680

Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.

Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.

Cancer Sci. 101:1891-1896(2010)

 

PubMed=20679594; DOI=10.1093/jnci/djq279; PMCID=PMC2935474

Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.

Lung cancer cell lines as tools for biomedical discovery and research.

J. Natl. Cancer Inst. 102:1310-1321(2010)

 

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027

Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature 483:603-607(2012)

 

PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112; PMCID=PMC3567922

Byers L.A., Wang J., Nilsson M.B., Fujimoto J., Saintigny P., Yordy J., Giri U., Peyton M., Fan Y.-H., Diao L.-X., Masrorpour F., Shen L., Liu W.-B., Duchemann B., Tumula P., Bhardwaj V., Welsh J., Weber S., Glisson B.S., Kalhor N., Wistuba I.I., Girard L., Lippman S.M., Mills G.B., Coombes K.R., Weinstein J.N., Minna J.D., Heymach J.V.

Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

Cancer Discov. 2:798-811(2012)