SK-N-SH/SK-N-SH/SK-N-SH/人神经母细胞

SK-N-SH/SK-N-SH细胞系/SK-N-SH细胞株/SK-N-SH人神经母细胞瘤细胞

Cell line name SK-N-SH

Synonyms SK N SH; SKN-SH; SK-NSH; SKNSH; NSH

Accession CVCL_0531

Resource Identification Initiative To cite this cell line use: SK-N-SH (RRID:CVCL_0531)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: ENCODE project common cell types; tier 3.

From: Memorial Sloan Kettering Cancer Center; New York; USA.

Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK1980-529.

Population: Caucasian.

Doubling time: 44 hours (PubMed=4748425).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Array-based CGH.

Omics: Chromatin accessibility by ATAC-seq.

Omics: ChIP-seq epigenome analysis.

Omics: CRISPR phenotypic screen.

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Misspelling: SK-N-CH; Note=Occasionally.

Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.

PubMed=15892104; DOI=10.1002/gcc.20198

Mosse Y.P., Greshock J., Margolin A.A., Naylor T., Cole K.A., Khazi D., Hii G., Winter C., Shahzad S., Asziz M.U., Biegel J.A., Weber B.L., Maris J.M.

High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.

Genes Chromosomes Cancer 43:390-403(2005)

 

PubMed=16822308; DOI=10.1186/1471-2407-6-177; PMCID=PMC1533846

Dam V., Morgan B.T., Mazanek P., Hogarty M.D.

Mutations in PIK3CA are infrequent in neuroblastoma.

BMC Cancer 6:177.1-177.10(2006)

 

PubMed=18724359; DOI=10.1038/nature07261; PMCID=PMC2672043

Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A., Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P., Laureys G., Speleman F., Kim C., Hou C.-P., Hakonarson H., Torkamani A., Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M., Maris J.M.

Identification of ALK as a major familial neuroblastoma predisposition gene.

Nature 455:930-935(2008)

 

PubMed=18957096; DOI=10.1186/1756-0500-1-95; PMCID=PMC2615028

Nishida Y., Adati N., Ozawa R., Maeda A., Sakaki Y., Takeda T.

Identification and classification of genes regulated by phosphatidylinositol 3-kinase- and TRKB-mediated signalling pathways during neuronal differentiation in two subtypes of the human neuroblastoma cell line SH-SY5Y.

BMC Res. Notes 1:95.1-95.11(2008)

 

PubMed=18923523; DOI=10.1038/nature07398

Janoueix-Lerosey I., Lequin D., Brugieres L., Ribeiro A., de Pontual L., Combaret V., Raynal V., Puisieux A., Schleiermacher G., Pierron G., Valteau-Couanet D., Frebourg T., Michon J., Lyonnet S., Amiel J., Delattre O.

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma.

Nature 455:967-970(2008)

 

PubMed=18923524; DOI=10.1038/nature07399

Chen Y.-Y., Takita J., Choi Y.L., Kato M., Ohira M., Sanada M., Wang L.-L., Soda M., Kikuchi A., Igarashi T., Nakagawara A., Hayashi Y., Mano H., Ogawa S.

Oncogenic mutations of ALK kinase in neuroblastoma.

Nature 455:971-974(2008)

 

PubMed=22213050; DOI=10.1002/ijc.27415; PMCID=PMC3757132

Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J., Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.

PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.

Int. J. Cancer 131:1556-1568(2012)

 

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027

Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature 483:603-607(2012)

 

PubMed=23325432; DOI=10.1101/gr.147942.112; PMCID=PMC3589544

Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M.

Dynamic DNA methylation across diverse human cell lines and tissues.

Genome Res. 23:555-567(2013)