MKN-28（MKN-74)细胞

MKN-28/MKN-28细胞系/MKN-28细胞株/MKN-28人胃癌细胞

Cell line name MKN28

Synonyms MKN-28; MKN 28

Accession CVCL_1416

Resource Identification Initiative To cite this cell line use: MKN28 (RRID:CVCL_1416)

Comments Problematic cell line: Contaminated. Shown to be a MKN74 derivative (PubMed=20143388).

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: JFCR39 cancer cell line panel.

Part of: JFCR45 cancer cell line panel.

Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00328.

Population: Japanese.

Doubling time: 28-32 hours (PubMed=3962675); 28 hours (PubMed=29435981); 30-34 hours (CelloPub=CLPUB00584).

Microsatellite instability: Stable (MSS) (PubMed=23671654; Sanger).

Omics: CRISPR phenotypic screen.

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.

PubMed=3986962; DOI=10.1093/carcin/6.4.549

Watatani M., Ikenaga M., Hatanaka T., Kinuta M., Takai S.-i., Mori T., Kondo S.

Analysis of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced DNA damage in tumor cell strains from Japanese patients and demonstration of MNNG hypersensitivity of Mer xenografts in athymic nude mice.

Carcinogenesis 6:549-553(1985)

 

PubMed=3962675; DOI=10.1111/j.1440-1827.1986.tb01461.x

Motoyama T., Hojo H., Watanabe H.

Comparison of seven cell lines derived from human gastric carcinomas.

Acta Pathol. Jpn. 36:65-83(1986)

 

PubMed=1933850

Yamada Y., Yoshida T., Hayashi K., Sekiya T., Yokota J., Hirohashi S., Nakatani K., Nakano H., Sugimura T., Terada M.

p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases.

Cancer Res. 51:5800-5805(1991)

 

PubMed=1370612; DOI=10.1016/S0006-291X(05)80133-0

Matozaki T., Sakamoto C., Matsuda K., Suzuki T., Konda Y., Nakano O., Wada K., Uchida T., Nishisaki H., Nagao M., Kasuga M.

Missense mutations and a deletion of the p53 gene in human gastric cancer.

Biochem. Biophys. Res. Commun. 182:215-223(1992)

 

DOI=10.1016/B978-0-12-333530-2.50014-9

Sekiguchi M., Suzuki T.

Gastric tumor cell lines.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York; USA (1994)

 

PubMed=9023415; DOI=10.1006/cimm.1996.1062

Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.

HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.

Cell. Immunol. 175:101-110(1997)

 

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D

Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Screening the p53 status of human cell lines using a yeast functional assay.

Mol. Carcinog. 19:243-253(1997)

 

PubMed=11107048; DOI=10.1046/j.1440-1827.2000.01117.x

Yokozaki H.

Molecular characteristics of eight gastric cancer cell lines established in Japan.

Pathol. Int. 50:767-777(2000)

 

PubMed=11314020; DOI=10.1038/sj.onc.1204160

Kataoka H., Miura Y., Joh T., Seno K., Tada T., Tamaoki T., Nakabayashi H., Kawaguchi M., Asai K., Kato T., Itoh M.

Alpha-fetoprotein producing gastric cancer lacks transcription factor ATBF1.

Oncogene 20:869-873(2001)