Caco-2细胞

Caco2/Caco-2人结直肠腺癌细胞Cell line name Caco-2

Synonyms CaCo-2; CACO-2; Caco 2; CACO 2; CACO2; CaCo2; CaCO2; Caco2; Caco-2/ATCC; Caco-II

Accession CVCL_0025

Resource Identification Initiative To cite this cell line use: Caco-2 (RRID:CVCL_0025)

Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: ENCODE project common cell types; tier 3.

Part of: MD Anderson Cell Lines Project.

Population: Caucasian.

Virology: Highly susceptible to infection by SARS coronavirus (SARS-CoV) (PubMed=15316659; PubMed=15731278).

Virology: Susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257; PubMed=34339474).

Doubling time: 51.41 hours (PubMed=25944804); 3-4 days (ATCC=HTB-37); ~60-70 hours (CLS=300137); ~80 hours (DSMZ=ACC-169); ~32 hours (PBCF).

Microsatellite instability: Stable (MSS) (PubMed=24042735; PubMed=24755471; PubMed=25926053; PubMed=28683746).

Omics: CTCF ChIP-seq epigenome analysis.

Omics: H3K27me3 ChIP-seq epigenome analysis.

Omics: H3K36me3 ChIP-seq epigenome analysis.

Omics: H3K4me3 ChIP-seq epigenome analysis.

Omics: Deep antibody staining analysis.

Omics: Deep exome analysis.

Omics: Deep phosphoproteome analysis.

Omics: Deep proteome analysis.

Omics: miRNA expression profiling.

Omics: N-glycan profiling.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Omics: Transcriptome analysis by serial analysis of gene expression (SAGE).

Derived from site: In situ; Colon; UBERON=UBERON_0001155.

PubMed=3518877; DOI=10.3109/07357908609038260

Fogh J.

Human tumor lines for cancer research.

Cancer Invest. 4:157-184(1986)

 

PubMed=3349466

Chantret I., Barbat A., Dussaulx E., Brattain M.G., Zweibaum A.

Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines.

Cancer Res. 48:1936-1942(1988)

 

PubMed=2914637; DOI=10.1016/0016-5085(89)90897-4

Hidalgo I.J., Raub T.J., Borchardt R.T.

Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability.

Gastroenterology 96:736-749(1989)

 

PubMed=7764660; DOI=10.1007/BF00749813

Hashimoto K., Shimizu M.

Epithelial properties of human intestinal Caco-2 cells cultured in a serum-free medium.

Cytotechnology 13:175-184(1993)

 

PubMed=8253353; DOI=10.1016/0016-5085(93)91076-t

Chastre E., Empereur S., Di Gioia Y., El Mahdani N., Mareel M.M., Vleminckx K.L., Van Roy F.M., Bex V., Emami S., Spandidos D.A., Gespach C.

Neoplastic progression of human and rat intestinal cell lines after transfer of the ras and polyoma middle T oncogenes.

Gastroenterology 105:1776-1789(1993)

 

PubMed=8508948; DOI=10.1111/j.1432-0436.1993.tb00645.x

de Bruine A.P., de Vries J.E., Dinjens W.N.M., Moerkerk P.T.M., van der Linden E.P.M., Pijls M.M.J., ten Kate J., Bosman F.T.

Human Caco-2 cells transfected with c-Ha-Ras as a model for endocrine differentiation in the large intestine.

Differentiation 53:51-60(1993)

 

PubMed=9294210; DOI=10.1073/pnas.94.19.10330; PMCID=PMC23362

Ilyas M., Tomlinson I.P.M., Rowan A.J., Pignatelli M., Bodmer W.F.

Beta-catenin mutations in cell lines established from human colorectal cancers.

Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997)

 

PubMed=10092214; DOI=10.1002/(SICI)1097-4652(199812)177:4<618::AID-JCP12>3.0.CO;2-R

Levy P., Robin H., Kornprobst M., Capeau J., Cherqui G.

Enterocytic differentiation of the human Caco-2 cell line correlates with alterations in integrin signaling.

J. Cell. Physiol. 177:618-627(1998)

 

PubMed=10612807; DOI=10.1002/(SICI)1098-2264(200002)27:2<183::AID-GCC10>3.0.CO;2-P; PMCID=PMC4721570

Ghadimi B.M., Sackett D.L., Difilippantonio M.J., Schrock E., Neumann T., Jauho A., Auer G., Ried T.

Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations.

Genes Chromosomes Cancer 27:183-190(2000)

 

PubMed=10737795; DOI=10.1073/pnas.97.7.3352; PMCID=PMC16243

Rowan A.J., Lamlum H., Ilyas M., Wheeler J., Straub J., Papadopoulou A., Bicknell D.C., Bodmer W.F., Tomlinson I.P.M.

APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.

Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000)

 

PubMed=11414198; DOI=10.1007/s004320000207

Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.-J.

Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.

J. Cancer Res. Clin. Oncol. 127:375-386(2001)

 

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459

Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G., Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R., Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.

Short tandem repeat profiling provides an international reference standard for human cell lines.

Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

 

PubMed=11668190; DOI=10.1177/002215540104901105

Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.

Immunocytochemical analysis of cell lines derived from solid tumors.

J. Histochem. Cytochem. 49:1369-1378(2001)

 

PubMed=12584437; DOI=10.1159/000068544

Melcher R., Koehler S., Steinlein C., Schmid M., Mueller C.R., Luehrs H., Menzel T., Scheppach W., Moerk H., Scheurlen M., Koehrle J., Al-Taie O.

Spectral karyotype analysis of colon cancer cell lines of the tumor suppressor and mutator pathway.

Cytogenet. Genome Res. 98:22-28(2002)

 

PubMed=14599474; DOI=10.1016/S0887-2333(03)00095-X

Ranaldi G., Consalvo R., Sambuy Y., Scarino M.L.

Permeability characteristics of parental and clonal human intestinal Caco-2 cell lines differentiated in serum-supplemented and serum-free media.

Toxicol. In Vitro 17:761-767(2003)

 

PubMed=15316659; DOI=10.1007/s00018-004-4222-9; PMCID=PMC7079841

Cinatl J. Jr., Hoever G., Morgenstern B., Preiser W., Vogel J.-U., Hofmann W.-K., Bauer G., Michaelis M., Rabenau H.F., Doerr H.-W.

Infection of cultured intestinal epithelial cells wit

Cell. Mol. Life Sci. 61:2100-2112(2004)

 

PubMed=15731278; DOI=10.1128/JVI.79.6.3846-3850.2005; PMCID=PMC1075706

Mossel E.C., Huang C., Narayanan K., Makino S., Tesh R.B., Peters C.J.

Exogenous ACE2 expression allows refractory cell lines to support se replication.

J. Virol. 79:3846-3850(2005)