依维菌素 *Sigma货号：I8898-250MG

一般描述

Ivermectin is a macro-cyclic lactone,[1] derived from avermectin.[2] It functions as an antiparasitic agent. Ivermectin is used against gastrointestinal roundworms, lungworms, mites and lice. It is used to treat onchocerciasis, strongyloidiasis, ascariasis and filariases.[2] 应用
Ivermectin has been used:
in Caenorhabditis elegans fecundity assay[3]
in larval development test[4]
to measure in vivo topical acaricide activity of compounds in rats[5]
to assess its acute and chronic effects to zebrafish[6]
in percutaneous drug injection method to treat cystic echinococcosis[7]
in liquid chromatography with fluorescence detection method[8]

生化/生理作用

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.

特点和优势

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.