ABCA1抗体;ABCA1 Polyclonal Antib

Description The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in both alleles of this gene cause Tangier disease and familial high-density lipoprotein (HDL) deficiency. References 1,Life Sci. 2020 Oct 15;259:118390. 2,Medicine (Baltimore). 2020 Jan;99(4):e18662. Specification Aliases:TGD; ABC1; CERP; ABC-1; HDLDT1; HPALP1; HDLCQTL13 Entrez GeneID:19 Swissprot:O95477 clone:6B7A11 WB Predicted band size:254 kDa Host/Isotype:Mouse IgG2a Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human ABCA1 (AA: 2081-2261) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application ICC:1/200 - 1/1000 FCM:1/200 - 1/400