ERCC1抗体;ERCC1 Polyclonal Antib

Description The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009] References Lung Cancer. 2013 Nov;82(2):324-9. Cancer. 2013 Sep 1;119(17):3242-50. Specification Aliases:UV20; COFS4; RAD10 Entrez GeneID:2067 Swissprot:P07992 clone:1E5B3 WB Predicted band size:32.6kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human ERCC1 (AA: 151-297) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application ICC:1/200 - 1/1000 FCM:1/200 - 1/400 ELISA:1/10000