GAD2抗体;GAD2 Polyclonal Antibod

Description This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. References 1.Histopathology. 2013 Sep;63(3):334-42. 2.Biol Psychiatry. 2012 Nov 1;72(9):734-43. Specification Aliases:GAD65 Entrez GeneID:2572 Swissprot:Q05329 clone:5D9G9 WB Predicted band size:65.4kDa Host/Isotype:Mouse IgG1 Antibody Type:Primary antibody Storage:Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. Species Reactivity:Human Immunogen:Purified recombinant fragment of human GAD2 (AA: 1-100) expressed in E. Coli. Formulation:Purified antibody in PBS with 0.05% sodium azide Application ELISA:1/10000