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- SIGMA
- 美国
- F9054-250μg
- 2025年07月10日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
瓶身
- 保质期：
coa
- 英文名：
SIGMA
- 库存：
999
- 供应商：
麦格生物
- CAS号：
118974-02-0
- 规格：
F9054-250μg
说明
一般描述
Chemical structure: indol derivative
应用
Fumitremorgin C has been used as adenosine triphosphate (ATP)-binding cassette superfamily G member 2 (ABCG2) inhibitor to study its effects on the cell viability of mouse neural stem/progenitor cells (NSPCs).[1] It has also been used as an ABCG2 inhibitor to study its effects on lung cancer cells.[2][3]
生化/生理作用
Fumitremorgin C (FTC) is a fungal toxin of the diketopiperazines family of compounds. In mammalian cells, FTC is tremorgenic and causes cell cycle arrest. Fumitremorgin C has been shown to reverse resistance to doxorubicin, mitoxantrane, and topotecan in non-Pgp (P-glycoprotein), non-MRP (multidrug resistance protein) multidrug-resistance (MDR) cells. This reversal of resistance is associated with an increase in drug accumulation. Fumitremorgin C is a specific, selective, and potent inhibitor at micromolar concentrations of the breast cancer resistant protein (BCRP/ABCG2), an ABC transporter associated with chemotherapy resistance. FTC, in combination with mitoxantrone, can be used for the detection of ABCG2 functional activity in several cell lines.
特点和优势
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
包装
Store desiccated at 2-8 °C. Under these conditions, the product is stable for 2 years. A solution in DMSO is stable for 2 months at 2-8 °C.
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文献和实验Ultrasonographic features for differentiating follicular thyroid carcinoma and follicular adenoma.
Ting-Chun Kuo et al.
Asian journal of surgery, 43(1), 339-346 (2019-06-12)
Detection and Purification of Non-ribosomal Peptide Synthetase Products in Neosartorya fischeri
enzymes, resulting in the formation of diverse structures. We demonstrate here the production and isolation of metabolites produced by two bi-modular NRPSs, i.e., acetylaszonalenin and fumitremorgin-type alkaloids in Neosartorya fischeri NRRL181.
inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C. Molecular Cancer Therapeutics, 2002, 1, 417–425. 32 Doyle, L. A.,&Ross, D. D. (2003). Multidrug resistance
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