- ￥2268
- SIGMA
- 美国
- G1774-0.1mg
- 2025年07月15日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
瓶身
- 保质期：
coa
- 英文名：
SIGMA
- 库存：
999
- 供应商：
麦格生物
- CAS号：
16941-32-5
- 规格：
G1774-0.1mg
说明
Amino Acid Sequence
His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr
一般描述
Glucagon (GCG) peptide is secreted in response to insulin from pancreatic islets α-cells.[1]
Glucagon is synthesized from proglucagon and is 29-amino acid peptide hormone.[2] Proglucagon gene is mapped to human chromosome 2q24.2.[3]
应用
Glucagon (GCG) has been:
used as a component of hormone stock solution for preserving full biological activity of heart tissues obtained from male Sprague-Dawley rats[1]
used as an infusion in phases II and III fasting king penguins to study the various lipolytic, metabolic, and hormonal responses[4]
used for the stimulation of PGC-1α expression in hepatocytes[5]
used to induce the expression of methionine adenosyltransferase α1 (MAT1A), which is involved in the regulation of hepatic levels of S-adenosylmethionine and the adaptive response to fasting[6]
used to study its effect on stimulation of gluconeogenesis through hepatic lipolysis, mediated by inositol trisphosphate receptor 1 (INSP3R1)[7]
intraperitoneally injected in mice to assess glucagon-induced Sam68 subcellular localization in vivo[8]
生化/生理作用
Glucagon (GCG) produces elevation in contractility and the frequency of contraction in heart muscles. It activates PI3K (phosphoinositide 3-kinase) and thus, elevates glucose utilization by heart muscles.[1] In multiple mammals, though not humans, this peptide induces lipolysis, and is the major lipolytic hormone in birds. It also induces gluconeogenesis and glycogenolysis in mammals and birds.[4]
The paired box 6 (PAX6) regulates the expression of glucagon.[9] High levels of glucagon referred to as hyperglucagonemia leads to a high risk of diabetes and is associated with pancreatic neuroendocrine tumors.[2] Defective glucagon hypersecretion is regarded as an etiopathogenic factor.[9]
组分
H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH.xHCl
其他说明
Lyophilized from 0.1% TFA in H2O
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文献和实验Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting
Capelo-Diz A, et al.
Cell Metabolism, 1373-1389., 35(8)-35(8) (2023)
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