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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 保质期：
1年
- 英文名：
Retinoic acid
- 库存：
100⁺瓶
- 供应商：
上海睿安生物13611631389
- CAS号：
302-79-4
- 规格：
5g/瓶
Sigma货号R2625现货Retinoic acid维甲酸13611631389上海睿安生物
说明
应用
- 视黄酸(RA)已用于胚胎干细胞至运动神经元的分化。
- 它已用于非洲爪蟾外胚层至胰腺的分化。
- 它还用于研究由RARα (视黄酸受体α)引起的表观遗传学调控。
- 它已用于研究原初精原细胞向精母细胞转化的RA信号转导。
生化/生理作用
全−反式−视黄酸(ATRA)是视黄酸受体(RAR)和视黄醇类X受体(RXR)的配体。所结合的RAR和RXR可作为调节正常细胞和恶性细胞的生长和分化的转录因子。细胞色素P450(CYP)可催化ATRA的4-羟基化。视黄酸可使胚胎干细胞成为神经元。
特点和优势
该化合物在受体分类和信号转导手册中 核受体(非甾体化合物)页面中进行了详细介绍。欲浏览其他手册页面，请 点击这里。
同行评审论文
Formation of organotypic testicular organoids in microwell culture†.
Sadman Sakib et al.
Biology of reproduction, 100(6), 1648-1660 (2019-03-31)
Three-dimensional (3D) organoids can serve as an in vitro platform to study cell-cell interactions, tissue development, and toxicology. Development of organoids with tissue architecture similar to testis in vivo has remained a challenge. Here, we present a microwell aggregation approach
Recovery from paralysis in adult rats using embryonic stem cells.
Deshpande DM et al.
Annals of Neurology, 60, 32-32 (2006)
Integrity of zinc finger motifs in PML protein is necessary for inducing its degradation by antimony.
Chang Yang et al.
Metallomics : integrated biometal science, 11(8), 1419-1429 (2019-07-18)
Antimony (Sb) belongs to the same group as arsenic (As) in the periodic table, and both share similar characteristics. However, Sb2O3 (SbIII) has no methylation capacity, unlike arsenic trioxide (As2O3). In the present study, we determined the effect of SbIII
Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice.
Lijun Ling et al.
AIDS (London, England), 33(4), F1-F12 (2019-03-05)
The combined combination antiretroviral therapy (cART) and anti-α4β7 RM-Act-1 antibody therapy allows macaques to durably control simian_immunodeficiency_virus(SIV) rebound after withdrawal of the interventions. Here, we aimed to investigate whether vedolizumab (VDZ), a clinical-grade humanized anti-α4β7 antibody, would
Epigenetic regulation by RARa maintains ligand-independent transcriptional activity.
Laursen KB et al.
Nucleic Acids Research, 40, 102-102 (2012)
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文献和实验该产品被引用文献
Sigma货号R2625现货Retinoic acid维甲酸13611631389上海睿安生物
说明
应用
- 视黄酸(RA)已用于胚胎干细胞至运动神经元的分化。
- 它已用于非洲爪蟾外胚层至胰腺的分化。
- 它还用于研究由RARα (视黄酸受体α)引起的表观遗传学调控。
- 它已用于研究原初精原细胞向精母细胞转化的RA信号转导。
生化/生理作用
全−反式−视黄酸(ATRA)是视黄酸受体(RAR)和视黄醇类X受体(RXR)的配体。所结合的RAR和RXR可作为调节正常细胞和恶性细胞的生长和分化的转录因子。细胞色素P450(CYP)可催化ATRA的4-羟基化。视黄酸可使胚胎干细胞成为神经元。
特点和优势
该化合物在受体分类和信号转导手册中 核受体(非甾体化合物)页面中进行了详细介绍。欲浏览其他手册页面，请 点击这里。
同行评审论文
Formation of organotypic testicular organoids in microwell culture†.
Sadman Sakib et al.
Biology of reproduction, 100(6), 1648-1660 (2019-03-31)
Three-dimensional (3D) organoids can serve as an in vitro platform to study cell-cell interactions, tissue development, and toxicology. Development of organoids with tissue architecture similar to testis in vivo has remained a challenge. Here, we present a microwell aggregation approach
Recovery from paralysis in adult rats using embryonic stem cells.
Deshpande DM et al.
Annals of Neurology, 60, 32-32 (2006)
Integrity of zinc finger motifs in PML protein is necessary for inducing its degradation by antimony.
Chang Yang et al.
Metallomics : integrated biometal science, 11(8), 1419-1429 (2019-07-18)
Antimony (Sb) belongs to the same group as arsenic (As) in the periodic table, and both share similar characteristics. However, Sb2O3 (SbIII) has no methylation capacity, unlike arsenic trioxide (As2O3). In the present study, we determined the effect of SbIII
Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice.
Lijun Ling et al.
AIDS (London, England), 33(4), F1-F12 (2019-03-05)
The combined combination antiretroviral therapy (cART) and anti-α4β7 RM-Act-1 antibody therapy allows macaques to durably control simian_immunodeficiency_virus(SIV) rebound after withdrawal of the interventions. Here, we aimed to investigate whether vedolizumab (VDZ), a clinical-grade humanized anti-α4β7 antibody, would
Epigenetic regulation by RARa maintains ligand-independent transcriptional activity.
Laursen KB et al.
Nucleic Acids Research, 40, 102-102 (2012)
相关实验
有DNAse酶、蛋白酶以及IgG，如Equitech bio公司货号为BAH67的BSA(我们公司长期有现货供应)和wako货号为：010-15131的牛血清蛋白。 作用：用于放射免疫、酶联免疫以及作为稀释剂或者封闭剂等。 5、 牛血清白蛋白(细胞培养级)，纯度98%即可，但是要求脂肪酸含量和内毒素含量极低，如：sigma货号为A8806的BSA(国外长期缺货，国内也没现货的)以及Equitech bio货号为BAH66的BSA。 作用：细胞培养及细胞培养相关的实验
：用于放射免疫、酶联免疫以及作为稀释剂或者封闭剂等。 5、 牛血清白蛋白（细胞培养级），纯度98%即可，但是要求脂肪酸含量和内毒素含量极低，如：sigma货号为A8806的BSA（国外长期缺货，国内也没现货的）以及Equitech bio货号为BAH66的BSA（我们公司长期有现货供应）。 作用：细胞培养及细胞培养相关的实验等。 6、 金标级牛血清白蛋白，高纯度，纯度99%以上。
/mL all-trans retinoic acid - - - - - 50nM monothio-glycerol - - - - - 0.4μM Activin A 100ng/ml 100ng/ml 100ng/ml - - - C687 Shh - - - 100ng/ml - - C100/C089 FGF
文献支持
Sigma货号R2625现货Retinoic acid维甲酸13611631389上海睿安生物
￥10963.86
