SETD7抗体SETD7兔多抗抗体SETD7_HUMAN a

保存缓冲液

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

功能

Histone methyltransferase that specifically monomethylates \'Lys-4\' of histone H3. H3 \'Lys-4\' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates \'Lys-189\' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates \'Lys-372\' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.