人CLDN18.2重组蛋白(CLDN18.2)Human C

英文名称：

Recombinant Human Claudin-18.2 (CLDN18.2)-Detergent (Active)

品名简称：

Recombinant Human CLDN18.2 protein-Detergent (Active)

货号：

CSB-MP005498HU(A5)-D

规格:

20μg

价格：

4104

LC-MS/Western Blot：

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SDS-PAGE：

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

纯度：

Greater than 80% as determined by SDS-PAGE.

内毒素：

Not test

生物活性：

Measured by its binding ability in a functional ELISA. Immobilized Human CLDN18.2 at 5 μg/mL on an Nickel Coated plate can bind Anti-CLDN18.2 recombinant antibody (CSB-RA005505MA1HU), the EC50 is 0.4640-0.6372 ng/mL.

基因名：

CLDN18.2

Uniprot No.：

P56856-2

别名：

(CLDN18.2)

种属：

Homo sapiens (Human)

蛋白长度：

Full Length of Isoform A2

来源：

Mammalian cell

分子量：

29.1 kDa

表达区域：

1-261aa

氨基酸序列：

MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV

蛋白标签：

C-terminal 10xHis-tagged

产品提供形式：

Liquid

缓冲液：

50 mM HEPES, 0.15 M NaCl, 0.05% DDM, 0.01% CHS, pH7.5

储存条件：

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保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.

货期：

3-7 business days

注意事项：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

功能1：

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

功能2：

/

文献：

"Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development." Sahin U., Koslowski M., Dhaene K., Usener D., Brandenburg G., Seitz G., Huber C., Tuereci O. Clin. Cancer Res. 14:7624-7634(2008)

研究领域：

Signal Transduction

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