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- 详细信息
- 文献和实验
- 技术资料
- 亚型:
IgG2a, kappa
- 形态:
Liquid
- 保存条件:
at-20℃
- 库存:
99
- 宿主:
Mouse
- 应用范围:
IHC,WB
- 浓度:
见说明
- 抗体英文名:
Anti-Pan-Thyroid hormone receptor Monoclonal antibody (N403/60)
- 规格:
50-100ug
小鼠抗Pan-Thyroid hormone receptor单克隆抗体(克隆号N403/60)上海圻明生物优势供应欢迎咨询。配对抗体小课堂:
Paired antibodies are two antibodies that can bind to an antigenic molecule at the same time. Specifically:
Paired antibodies are commonly used in sandwich ELISA experiments
An antigenic molecule usually has multiple epitopes, and different antibodies can target different epitopes
When two antibodies are able to bind to different epitopes of the same antigenic molecule at the same time, the two antibodies are called paired antibodies
However, not all antibodies against different epitopes can be paired antibodies. Sometimes, when an antibody binds to an antigen, it may cause the configuration of other binding sites to change, making it impossible for other antibodies to bind properly
Steric hindrance effects may also result in two antibodies with close binding sites not being able to bind to the antigen at the same time
Therefore, the preparation of paired antibodies usually requires two steps: first the antibody is prepared, and then the paired antibody is screened
Screening of paired antibodies is typically performed using a sandwich ELISA method of bispecific antibodies, in which different combinations of antibodies are tested to determine which antibodies can be successfully paired
Paired antibodies have important applications in immunology research and diagnostics, especially in assays that require high specificity and sensitivity.

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文献和实验激素作用于细胞时,与神经传递物质一样,第一阶段是与细胞中的特定化学物质进行特异的结合,称此化学物质为激素受体。激素受体可分为两类,一类是对类固醇激素的受体,溶存于细胞质中;另一类是肽激素的受体,存在肽激素的靶细胞的细胞膜,在膜外面有与激素结合的部位,是难溶于水的复合蛋白质,可被乙醇或表面活性剂从膜上溶出。各种肽激素均具其特有的受体。激素分子与受体分子的结合是非价键结合。另外在热力学上则称为尔刚 ( ergon)反应,不需要从外部供给能量。结合的平衡常数多为 109 M-1
Transcriptional Regulation by Thyroid Hormone Receptor in Chromatin
structure has an important role in regulating gene expression and that transcription factors can actively recruit chromatinremodeling enzymes to regulate transcription of their target genes positively or negatively (3 -6 ). In this regard, thyroid hormone
Steroid Hormone Metabolites and Hormone Binding Assays
of the steroid/thyroid hormone receptor superfamily, and they act as ligand-dependent transcription factors to either activate or repress target gene expression ( 1 , 2 ). They regulate gene transcription by binding to hormone response element DNA sequences
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