- 询价
- KA&M BIO
- MAB4107
- 2026年05月10日
- IHC,WB
- Mouse
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- 文献和实验
- 技术资料
- 亚型：
IgG2a, kappa
- 形态：
Liquid
- 保存条件：
at-20℃
- 库存：
99
- 宿主：
Mouse
- 应用范围：
IHC,WB
- 浓度：
见说明
- 抗体英文名：
Anti-GluK1/GluR5 kainate receptor Monoclonal antibody (N298/14)
- 规格：
50-100ug
小鼠抗GluK1/GluR5 kainate receptor单克隆抗体(克隆号N298/14)上海圻明生物优势供应欢迎咨询。配对抗体小课堂：
Paired antibodies are two antibodies that can bind to an antigenic molecule at the same time. Specifically:
Paired antibodies are commonly used in sandwich ELISA experiments
An antigenic molecule usually has multiple epitopes, and different antibodies can target different epitopes
When two antibodies are able to bind to different epitopes of the same antigenic molecule at the same time, the two antibodies are called paired antibodies
However, not all antibodies against different epitopes can be paired antibodies. Sometimes, when an antibody binds to an antigen, it may cause the configuration of other binding sites to change, making it impossible for other antibodies to bind properly
Steric hindrance effects may also result in two antibodies with close binding sites not being able to bind to the antigen at the same time
Therefore, the preparation of paired antibodies usually requires two steps: first the antibody is prepared, and then the paired antibody is screened
Screening of paired antibodies is typically performed using a sandwich ELISA method of bispecific antibodies, in which different combinations of antibodies are tested to determine which antibodies can be successfully paired
Paired antibodies have important applications in immunology research and diagnostics, especially in assays that require high specificity and sensitivity.
小鼠抗GluK1/GluR5 kainate receptor单克隆抗体(克隆号N298/14)更多优势产品欢迎新老客户选购。
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文献和实验后能形成肿瘤，即所谓杂交瘤。生长杂交瘤的小鼠血清和腹水中含有大量同质的抗体，即单克隆抗体。 这一技术建立后不久，在融合剂和所用的骨髓瘤细胞系等方面即得到改进。最早仙台病毒被用做融合剂，后来发现聚乙二醇（PEG）的融合效果更好，且避免了病毒的污染问题，从而得到广泛的应用。随后建立的骨髓瘤细胞系如SP2/0-Ag14，X63-Ag8.653和NSO/1都是既不合成轻链又不合成重链的变种，所以由它们产生的杂交瘤细胞系，只分泌一种针对预定的抗原的抗体分子，克服了骨髓瘤细胞MOPC-21等的不足。再后来
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2来促进DNA修复。虚拟筛选发现了HIT-4——一种能够破坏E2F8-DNA结合的小分子化合物，该化合物在体外、异种移植模型和患者来源类器官中均与PARP抑制剂表现出协同效应。 J Exp Clin Cancer Res. 2025 Dec 14;45(1):19. doi: 10.1186/s13046-025-03586-2 3、Rbfox3促进MDSC样肿瘤细胞的转化以塑造免疫抑制微环境 发表期刊：Advanced Science
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