- ￥600 - 3200
- 上海莼试
- CS-01Y76528
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
59
- 英文名：
L-Acetylcarnitine (hydrochloride)
- CAS号：
5080-50-2
- 供应商：
上海莼试
- 保存条件：
Store at -20°C
- 规格：
1g 5g 10g 25g
产品描述：
分子式:C9H17NO4 • HCl
分子量:239.7
溶解度:≥ 11mg/mL in DMSO with gentle warming
储存条件:Store at -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
L-Acetylcarnitine, also named as ALCAR, an acetylated form of L-carnitine, fosters the uptake of acetyl coenzyme A (CoA) into mitochondria during fatty acid oxidation, raises the production of acetylcholine, and triggers the synthesis of membrane phospholipid and protein. ALCAR has been explored for use as an acetylcholine mimic as well as in targeting cardiovascular pathologies. Acetyl-CoA is the primary substrate for the tricarboxylic acid cycle in mitochondria and modulates the reserves of free CoA which is essential to the function of the tricarboxylic acid cycle.In vitro: The expression of tumor antigen CA-125 in ovarian cancer cells was not affected by ALCAR. Comparing to the control, the growth of SKOV-3 cells was remarkably decreased when incubated with ALCAR. The proliferation of SKOV-3 cells was decreased slightly but significantly when cells were incubated at higher ALCAR concentrations. In addition, ALCAR had no effect on the expression of the nerve growth factor receptors on SKOV-3 or OVCAR-3 ovarian cancer cells [1].In vivo: Male Flinders Sensitive Line (FSL) rats and male CD1 mice, exposed to model genetic and environmentally induced depression, respectively, were injected intraperitoneally with ALCAR 100 mg/kg for 21 days. ALCAR, as a long-lasting and rapid antidepressant, functioned via the epigenetic regulation of type 2 metabotropic glutamate (mGlu2) receptors in FSL rats and in mice. Additionally, ALCAR raised the transcription of Grm2 gene encoding for the mGlu2 receptor via increasing the levels of acetylated H3K27 bound to the Grm2 promoter and gaining the acetylation of NF-KB-p65 subunit. [2].
商品属性：
注意事项：
抗逆滴加序列
每次向板内滴加抗原时，移液器滴头要与平面45度悬空，不要触碰到孔内的液体，由后向前依次滴加(即浓度由低往高滴加)。
抗感染反应期
抗原抗体在室温20~25℃下，必须反应30min以上，若环境温度低于室温，可将微量反应板置于恒温培养箱中，使二者充分反应。
旅游温度
磷酸盐缓冲液的pH值要在高压灭菌后进行滴定，往往在高压后pH值会有所改变，所以高压后再调一次pH值更为准确。磷酸盐缓冲液一经使用保存期不要超过3周。当pH<5.8时，红细胞会产生自凝现象;当pH>7.8时，图形洗脱加快，易造成肉眼观察产生误差;p H=7.2时，红细胞沉降最充分，图形最清晰。
当滴注 1%红细胞悬液时，应经常摇晃红细胞悬液，使红细胞均匀地分布在磷酸缓冲液中，以防止红细胞下降。
反应时间及温度
加入鸡红血球之后，反应板在室温(20~25℃)静置30~40min，对照孔血球下沉于孔底，即可判定结果。若室温达不到实验要求，需相应调整反应时间。当环境温度低于4℃时，红细胞发生自凝;高于37℃时，会发生反应物分离和红细胞溶血。
公司正在出售的产品：
使用方法：
1.本蛋白酶抑制剂混合物为100×的储存液，使用时按照1:100的比例加入到裂解液中(例如，1ml裂解液中加入10μl蛋白酶抑制剂混合物)，混匀后即可使用。根据需要，0.5M的EDTA也按照1:100的比例加入到裂解液中（如用于检测金属蛋白酶活性，则不宜添加EDTA）。含有蛋白酶抑制剂混合物的裂解液宜现用现配，不宜配制后冻存待后续使用。
2. 待所需的抑制剂添加完毕混匀后，就可以开始进行哺乳动物组织的裂解和蛋白提取。
分子式:C9H17NO4 • HCl
分子量:239.7
溶解度:≥ 11mg/mL in DMSO with gentle warming
储存条件:Store at -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
L-Acetylcarnitine, also named as ALCAR, an acetylated form of L-carnitine, fosters the uptake of acetyl coenzyme A (CoA) into mitochondria during fatty acid oxidation, raises the production of acetylcholine, and triggers the synthesis of membrane phospholipid and protein. ALCAR has been explored for use as an acetylcholine mimic as well as in targeting cardiovascular pathologies. Acetyl-CoA is the primary substrate for the tricarboxylic acid cycle in mitochondria and modulates the reserves of free CoA which is essential to the function of the tricarboxylic acid cycle.In vitro: The expression of tumor antigen CA-125 in ovarian cancer cells was not affected by ALCAR. Comparing to the control, the growth of SKOV-3 cells was remarkably decreased when incubated with ALCAR. The proliferation of SKOV-3 cells was decreased slightly but significantly when cells were incubated at higher ALCAR concentrations. In addition, ALCAR had no effect on the expression of the nerve growth factor receptors on SKOV-3 or OVCAR-3 ovarian cancer cells [1].In vivo: Male Flinders Sensitive Line (FSL) rats and male CD1 mice, exposed to model genetic and environmentally induced depression, respectively, were injected intraperitoneally with ALCAR 100 mg/kg for 21 days. ALCAR, as a long-lasting and rapid antidepressant, functioned via the epigenetic regulation of type 2 metabotropic glutamate (mGlu2) receptors in FSL rats and in mice. Additionally, ALCAR raised the transcription of Grm2 gene encoding for the mGlu2 receptor via increasing the levels of acetylated H3K27 bound to the Grm2 promoter and gaining the acetylation of NF-KB-p65 subunit. [2].
商品属性：
| 货号 | CS-01Y76528 | 规格 | 1g 5g 10g 25g |
| CAS号 | 5080-50-2 | 分子量 | 239.7 |
| 含量 | >98.00% | 别名 | Acetyl-L-Carnitine,ALCAR |
| 分子式 | C9H17NO4 • HCl | 化学名 | (R)-3-acetoxy-4-(trimethylammonio)butanoate hydrochloride |
| 产地 | 国产 | 用途 | 仅供科研研究实验 |
抗逆滴加序列
每次向板内滴加抗原时，移液器滴头要与平面45度悬空，不要触碰到孔内的液体，由后向前依次滴加(即浓度由低往高滴加)。
抗感染反应期
抗原抗体在室温20~25℃下，必须反应30min以上，若环境温度低于室温，可将微量反应板置于恒温培养箱中，使二者充分反应。
旅游温度
磷酸盐缓冲液的pH值要在高压灭菌后进行滴定，往往在高压后pH值会有所改变，所以高压后再调一次pH值更为准确。磷酸盐缓冲液一经使用保存期不要超过3周。当pH<5.8时，红细胞会产生自凝现象;当pH>7.8时，图形洗脱加快，易造成肉眼观察产生误差;p H=7.2时，红细胞沉降最充分，图形最清晰。
当滴注 1%红细胞悬液时，应经常摇晃红细胞悬液，使红细胞均匀地分布在磷酸缓冲液中，以防止红细胞下降。
反应时间及温度
加入鸡红血球之后，反应板在室温(20~25℃)静置30~40min，对照孔血球下沉于孔底，即可判定结果。若室温达不到实验要求，需相应调整反应时间。当环境温度低于4℃时，红细胞发生自凝;高于37℃时，会发生反应物分离和红细胞溶血。
公司正在出售的产品：
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| GW441756 | B-淋巴细胞趋化因子1(BLC1)ELISA试剂盒 |
| GW501516 | B-淋巴酪氨酸激酶(BLK)ELISA试剂盒 |
| GW5074 | B-淋巴细胞激活抗原B7-2(LAB7-2)ELISA试剂盒 |
| GW604714X | B类清道夫受1(SCARB1)ELISA试剂盒 |
| GW791343 dihydrochloride | B-黑色素瘤抗原5(BAGE5)ELISA试剂盒 |
| GW791343 HCl | B-黑色素瘤抗原4(BAGE4)ELISA试剂盒 |
| GW806742X | B-细胞激活因子(BAFF)ELISA试剂盒 |
| GW806742X hydrochloride | B-细胞激活因子受(BAFFR)ELISA试剂盒 |
| GW841819X | B-细胞连接蛋白(BLNK)ELISA试剂盒 |
| GW843682X | B-细胞淋巴瘤因子10(Bcl10)ELISA试剂盒 |
| GW9662 | L-Acetylcarnitine (hydrochloride)B-细胞淋巴瘤因子2(Bcl2)ELISA试剂盒 |
| 11β-Prostaglandin E2 | B-细胞淋巴瘤因子3(Bcl3)ELISA试剂盒 |
| 人维甲酸受应答基因1ELISA试剂盒 | B-细胞淋巴瘤因子6(Bcl6)ELISA试剂盒 |
1.本蛋白酶抑制剂混合物为100×的储存液，使用时按照1:100的比例加入到裂解液中(例如，1ml裂解液中加入10μl蛋白酶抑制剂混合物)，混匀后即可使用。根据需要，0.5M的EDTA也按照1:100的比例加入到裂解液中（如用于检测金属蛋白酶活性，则不宜添加EDTA）。含有蛋白酶抑制剂混合物的裂解液宜现用现配，不宜配制后冻存待后续使用。
2. 待所需的抑制剂添加完毕混匀后，就可以开始进行哺乳动物组织的裂解和蛋白提取。
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L-Acetylcarnitine (hydrochloride)
￥600 - 3200
