Tubulin inhibitor 47

Tubulin inhibitor 47 产品活性：Tubulin inhibitor 47 (compound C11) 是一种有效的微管蛋白 (tubulin) 抑制剂。Tubulin inhibitor 47 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 M 期。Tubulin inhibitor 47 具有抗肿瘤活性。 产品来源： www.medchemexpress.cn/tubulin-inhibitor-47.html 研究领域：Cell Cycle/DNA Damage | Cytoskeleton | Apoptosis 作用靶点：Microtubule/Tubulin | Apoptosis In Vitro: Tubulin inhibitor 47 (compound C11) targets the colchicine site of tubulin to inhibit its polymerization. Tubulin inhibitor 47 (0, 2, 4, 6, 8, 10 nM) induces cell cycle arrest at the M phase. Tubulin inhibitor 47 (0, 5, 10, 20 nM) increases the expression of p-Histone H3 in KYSE30 cells in a dose-dependent manner. Tubulin inhibitor 47 (0, 5, 10, 20 nM; 48 h) induces apoptosis in a dose-dependent manner. In Vivo: Tubulin inhibitor 47 (6, 12 mg/kg; i.p.; daily for 15 days) shows anti-tumor activity in a dose-dependent manner. 相关产品：MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | Paclitaxel | LY294002 | Z-VAD-FMK | 2-Deoxy-D-glucose | Acetylcysteine | Angiotensin II human | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Oxaliplatin | Deferoxamine mesylate | Trametinib | Sorafenib | Gemcitabine | Temozolomide | Etoposide | Rotenone | Decitabine | Mdivi-1 | Monomethyl auristatin E | Ruxolitinib | Elesclomol | DAPT 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪前沿的制药及生命科学研究进展，为您提供全球前沿的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。