Spectinomycin sulfate,64058-48

Spectinomycin sulfate hydrate 产品活性：Spectinomycin sulfate hydrate 是一种广谱抗生素，可以抑制多种革兰氏阳性和革兰氏阴性细菌的生长。Spectinomycin sulfate hydrate 通过特异靶向细菌核糖体，干扰蛋白质合成。Spectinomycin sulfate hydrate 也是 td 内含子 RNA 的非竞争性抑制剂，Ki 为 7.2 mM。 产品来源： www.medchemexpress.cn/spectinomycin-sulfate-hydrate.html 研究领域：Anti-infection 作用靶点：Antibiotic | Bacterial In Vitro: Spectinomycin sulfate hydrate selectively inhibits protein synthesis in cells and in extracts of Escherichia coli: Spectinomycin sulfate hydrate (50 μg/mL) inhibits Escherichia coli growth rapidly and reversibly, and suppresses amino acid incorporation immediately. Spectinomycin sulfate hydrate (1 μg/mL or 3 μM) inhibits polypeptide synthesis directed either by endogenous messenger RNA or by MS-2 bacteriophage RNA, with maximum inhibition of 70-80% in extracts of Escherichia coli. Spectinomycin sulfate hydrate blocks the translocation of peptidyl-tRNAs from A-site to P-site by inhibiting the binding of elongation factor G to the ribosome. Spectinomycin sulfate hydrate interacts specifically with the residues G1064 and 01192 in 16S rRNA and potentially makes it inactive. Spectinomycin sulfate hydrate exhibits splicing inhibition and is dependent on pH changes and Mg2+ concentration, indicating electrostatic interactions with the intron RNA. In Vivo: Spectinomycin dihydrochloride pentahydrate (20 mg/kg; i.m.; 20-100 mg/kg; 9 d) shows the safety in healthy chicks. Spectinomycin dihydrochloride pentahydrate (10 mg/kg; i.v.; single dose) has the major elimination pathway by renal excretion, approximately 55% is excreted into the urine in unchanged form. Pharmacokinetics of Spectinomycin dihydrochloride pentahydrate in Rat Parameter C0 (μg/mL) AUC0-∞ (μg•h/mL) Vd (L/kg) CL (L/h/kg) MRT (h) T1/2α (h) T1/2β (h) T1/2γ (h) fe CLrenal (L/h/kg) Eratio Non atrioventricular analysis 44.3 16.8 0.756 0.602 0.757 / / / 0.553 0.359 1.00 Three-compartment model 37.8 15.7 0.747 0.649 1.11 / 0.237 0.754 19.5 / / 相关产品：Rapamycin | Cycloheximide | Chloroquine | Doxorubicin hydrochloride | Dimethyl sulfoxide | Bafilomycin A1 | Dexamethasone | Staurosporine | Actinomycin D | Puromycin dihydrochloride | Etoposide | Cyclosporin A | Nigericin sodium salt | G-418 disulfate | Brefeldin A | CCCP | 5-Azacytidine | Estradiol | Bleomycin sulfate | Ionomycin | Hygromycin B | Mitomycin C | Resveratrol | Tunicamycin | Everolimus | Tacrolimus | Doxycycline | Lactate sodium 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪前沿的制药及生命科学研究进展，为您提供全球前沿的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。