PEGylated Liposomal Doxorubici

Remote Loading of Anthracyclines into Liposomes

and encapsulation efficiencies compared to conventional passive trapping techniques like hydration of dried lipid films with aqueous drug solutions. The method presented is appropriate to produce sterile liposomal doxorubicin formulations with a final

抗多发性骨髓瘤BiTE抗体研发取得突破性进展

远多于女性患者，黑人患骨髓瘤的机率是白人的 2 倍以上。导致骨髓瘤发生的因素较多，例如遗传、辐射或化学物接触等。目前市场上已有 bortezomib，PEGylated liposomal doxorubicin[3]等药物用于治疗多发性骨髓瘤，且免疫调节药物（IMiD）来那度胺联合蛋白酶体抑制剂硼替佐米和地塞米松可有效治疗骨髓瘤。硼替佐米和来那度胺可杀伤骨髓瘤细胞并克服其对传统治疗的耐药，但多发性骨髓瘤仍然不可治愈。事实上，几乎所有的多发性骨髓瘤患者在接受治疗后，最终还是会产生耐药性，从而导致

macrophage dichloromethylene diphosphonate)

through the Bilbate Ж pipette placed on the bottom of the tube for 60-90 min, RT. centrifuge for 15 min at 10000 rpm (rotor ID=JA20), 24ѓC aspirate the solution under the liposomes' ring (in case of liposome-clodronate) or aspirate the supernatant