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文献和实验Tyrosine Kinase Inhibitors Against EGF Receptor-Positive Malignancies
epidermal growth factor receptor (EGFR) (1 –6 ), Janus kinases (JAKs) (7 –13 ), Bruton’s tyrosine kinase (BTK) (14 –16 ), platelet-derived growth factor (PDGF) (17 ), protein kinase C (PKC) (18 –24 ), Lck (25 , 26 ), Trk (27 –30
MAP Kinase Activation by Receptor Tyrosine Kinases: In Control of Cell Migration
A myriad of cellular processes instigated by growth factors are mediated by cell surface-associated receptor tyrosine kinases (RTKs). Subsequent downstream activation of signaling cascades, as well as their crosstalk, endows specificity
Role of Receptor Tyrosine Kinases in Lung Cancer
, in both lung and other tissues, have been identified (1 ). The receptors contain an N-terminal extracellular ligand-binding domain, a single transmembrane α helix, and a cytosolic C-terminal domain with tyrosine kinase activity. The binding of growth factors
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