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文献和实验Analysis of Human Mitochondrial DNA Mutations
their own genetic material—mitochondrial DNA (mtDNA)-mitochondria are unique mammalian organelles. Normal human mtDNA is a 16,569 base-pair (bp), double-stranded, circular molecule ( 1 ). The molecules contain tightly compacted genes for 22 transfer (
The mitochondrion is the eukaryotic organelle that carries out oxidative phosphorylation, fulfilling cellular requirements for ATP production. Disruption of mitochondrial energy metabolism can occur by genetic and biochemical mechanisms
Identification of Mutations in mtDNA from Patients Suffering Mitochondrial Diseases
The human mitochondrial genome. The structural genes for the mtDNA-encoded 12S and 16S ribosomal RNAs, the subunits of NADH-coenzyme Q oxidoreductase (ND), cytochrome-c oxidase (COX), cytochrome-b (Cyt b), and ATP synthase (A), and 22 tRNAs, are shown
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