Recombinant Borrelia Burgdorfe

Electrotransformation of the Spirochete Borrelia burgdorferi

Borrelia burgdorferi is an etiologic agent of Lyme disease, the most common arthropod-borne disease in the United States (1 ,2 ). The bacterium, a member of the spirochete phylum, has a genome predominantly composed of linear DNA molecules

Determining the Cellular Targets of Reactive Oxygen Species in Borrelia burgdorferi

The response of Borrelia burgdorferi to the challenge of reactive oxygen species (ROS) is a direct result of its limited biosynthetic capabilities and lack of biologically significant levels of intracellular Fe. In other bacteria

阻断bba64基因表达 开发莱姆病疫苗新策略

科学家提出，让通过虱子传播的莱姆病病源体——莱姆病螺旋体（Borrelia burgdorferi）的一个基因不再活动可以阻止这种疾病的传播。此前的研究表明莱姆病螺旋体的bba64基因在进食的虱子体内表达，然而这种基因的功能尚不为人所知。 Robert Gilmore, Jr及其同事为小鼠注射了一种莱姆病螺旋体菌株，这种修改后的菌株的bba64基因被关闭了，然后让虱子以小鼠为食并获得了这种细菌。 这组科学家然后把这些虱子转移给了没有莱姆病的虱子，结果发现8周后15只实验小鼠只有2只感染