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文献和实验Detection of DNA-Dependent Protein Kinase in Extracts from Human and Rodent Cells
The DNA-dependent protein kinase, DNA-PK, is required for DNA double-strand break repair and V(D)J recombination (1 –3 ). DNA-PK is composed of a large catalytic subunit of approx 460 kDa (DNA-PKcs) and a heterodimeric DNA targeting subunit
Application of Amide Proton Exchange Mass Spectrometry for the Study of Protein‐Protein Interactions
of the protein kinase A regulatory RIα‐catalytic subunit interface by amide H/2H exchange and protein docking. Proc. Natl. Acad. Sci. U.S.A. 100:13264‐13269. Baerga‐Ortiz
motifs located prevalently in the 3′ untranslated regions of target messenger RNAs (mRNA). Interferon-alpha-2a (IFNα) induces a large set of protein coding genes mediating antiproliferative and antiviral responses. Here we use a global microarray-based
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