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文献和实验Identification of MHC Class II Binding Peptides: Microarray and Soluble MHC Class II Molecules
binding peptides. We present here a high content screening for MHC class II (HLA-DR) binding to a peptide library in a chip-format. Binding of soluble MHC class II molecules to individual peptides can be visualized using an anti-DR directed monoclonal
The K/BxN Mouse Model of Inflammatory Arthritis: Theory and Practice
Mice expressing the KRN T cell receptor transgene and the MHC class II molecule Ag7 (K/B�N mice) develop severe inflammatory arthritis, and serum from these mice causes similar arthritis in a wide range of mouse strains, owing to pathogenic
), and then to deliver the peptide-MHC complexes to the plasma membrane in order to stimulate T cells. It is becoming increasingly clear that most of the intracellular compartments that contain MHC class II products in APC simply represent the conventional endosomes
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