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文献和实验The K/BxN Mouse Model of Inflammatory Arthritis: Theory and Practice
Mice expressing the KRN T cell receptor transgene and the MHC class II molecule Ag7 (K/B�N mice) develop severe inflammatory arthritis, and serum from these mice causes similar arthritis in a wide range of mouse strains, owing to pathogenic
of charge, but for research purpose only (Table 1 ). The construction of MHC class II-peptide tetrameric complexes has proven to be more problematic than class I, with a fewer publications mainly involving mouse tetramers and no standard protocol.
to result predominately from a human anti-mouse major histocompatibility complex (MHC) class II reactivity. Our recent development of NOD-scid IL2rγ null β2m null and NOD-scid IL2rγ null Ab null stocks of mice now make it possible to investigate
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