Ophiopogonin D

一种类固醇糖苷；在2.5、5或10µM浓度下诱导MDA-MB-231人乳腺癌细胞凋亡并减少TGF-β1诱导的迁移；在10和100µM浓度下抑制RAW 264.7细胞中过氧化氢诱导的ROS生成；在1mg/kg浓度下抑制酵母聚糖A诱发的腹膜炎小鼠模型中的腹膜中性粒细胞浸润；在1和2mg/kg浓度下降低静脉血栓形成小鼠模型中的血栓重量。A steroid glycoside; induces apoptosis in, and reduces TGF-β1-induced migration of, MDA-MB-231 human breast cancer cells at 2.5, 5, or 10 µM; inhibits hydrogen peroxide-induced ROS production in RAW 264.7 cells at 10 and 100 µM; peritoneal neutrophil infiltration in a mouse model of zymosan A-induced peritonitis at 1 mg/kg; reduces thrombus weight in a mouse model of venous thrombosis at 1 and 2 mg/kg.分子式C44H70O16分子量855C[C@@]12[C@]3([H])[C@](O[C@]4(CC[C@H](CO4)C)[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@]6([C@@H](C[C@@H](CC6=CC5)O)O[C@H]7[C@@H]([C@H]([C@H]([C@H](O7)C)O)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O)O)C)([H])CC2