- ￥218 - 9180
- TargetMol
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- 2025年07月14日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
SKF-96365 hydrochloride
- 库存：
10
- 供应商：
TargetMol
- CAS号：
130495-35-1
- 规格：
100 mg/500 mg/5 mg/1 mL/25 mg/200 mg/1 mg/10 mg/50 mg
| 规格： | 100 mg | 产品价格： | ￥4330.0 |
|---|---|---|---|
| 规格： | 500 mg | 产品价格： | ￥9180.0 |
| 规格： | 5 mg | 产品价格： | ￥498.0 |
| 规格： | 1 mL | 产品价格： | ￥589.0 |
| 规格： | 25 mg | 产品价格： | ￥1470.0 |
| 规格： | 200 mg | 产品价格： | ￥6180.0 |
| 规格： | 1 mg | 产品价格： | ￥218.0 |
| 规格： | 10 mg | 产品价格： | ￥713.0 |
| 规格： | 50 mg | 产品价格： | ￥2890.0 |
Product Introduction
Bioactivity
英文名:SKF-96365 hydrochloride
描述:SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 hydrochloride treatment inhibited the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade in vitro and in vivo. Overexpression of CaMKIIγ or AKT abolished the effects of SKF-96365 on Y cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects. SKF-96365 hydrochloride inhibited hERG current in a concentration-dependent manner.
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文献和实验Guanidine Hydrochloride Purification of Proteins From SDS
Pepstatin A (2.0 mg/ml)10 ml Leupeptin (1.0 mg/ml)10 ml Aprotinin (5.0 mg/ml)(Protease Inhibitor Cocktail Sigma #P8340)Denaturation Buffer6 M guanidine hydrochloride 57.3 g G-HCl20 mM Hepes 7.9 2 ml 1M Hepes pH 7.910 mM KCl 0.074 g KCl0.5 mM DTT 100 ml 0.5 M
Guanidine Hydrochloride Purification of Proteins From SDS PAGE
(Sigma #P7626) 10 ml Pepstatin A (2.0 mg/ml) 10 ml Leupeptin (1.0 mg/ml) 10 ml Aprotinin (5.0 mg/ml) (Protease Inhibitor Cocktail Sigma #P8340) Denaturation Buffer 6 M guanidine hydrochloride 57.3 g G-HCl 20 mM Hepes 7.9 2 ml 1M Hepes pH 7.9 10 mM
Packed column subcritical and/or supercritical fluid chromatography (p-sub or pSFC) has been used as a powerful chiral separation technique, whereby a mobile phase produces low viscosity, a high diffusion coefficient, and a solvating power. P
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