Azadirachtin B

一种具有多种生物活性的阿扎迪拉克汀；在3mg/ml时对菜粉蝶（P.xylostella）三龄幼虫具有拒食活性并诱导死亡（LC₅₀=1.03mg/ml）；在125.8ppm时对南方根结线虫（M.incognita）二龄幼虫诱导死亡；在饮用水中以780nmol剂量可减少由过氧亚硝酸盐和TPA诱导的小鼠皮肤癌模型中形成的乳头状瘤数量，但对HL-60、A549、AZ521、SK-BR-3或CRL1579癌细胞无细胞毒性（所有细胞的IC₅₀均>20µM）；在100pM和10nM浓度下诱导成骨细胞分化并增加原代颅骨成骨细胞的增殖速率，但在1pM、1µM或100µM浓度下无此作用。An azadirachtin with diverse biological activities; has antifeedant activity against P. xylostella third instar larvae at 3 mg/ml induces mortality (LC50 = 1.03 mg/ml); induces mortality in M. incognita second instar larvae (LD50 = 125.8 ppm); reduces the number of papillomas formed on mouse skin in a model of skin carcinogenesis induced by peroxynitrite and TPA at 780 nmol in the drinking water but is not cytotoxic to HL-60, A549, AZ521, SK-BR-3, or CRL1579 cancer cells (IC50s = >20 µM for all); It induces osteoblast differentiation and increases the rate of osteoblast proliferation in primary calvarial osteoblast cells at 100 pM and 10 nM but not 1 pM, 1 µM, or 100 µM.