Inostamycin A (sodium salt)

具有抗癌活性的细菌代谢物；CDP-二酰甘油：肌醇3-磷脂酰转移酶的抑制剂(IC50=0.02µg/ml)；在10µg/ml时对CDP-二酰甘油：肌醇3-磷脂酰转移酶具有选择性，优于PLC和磷脂酰肌醇激酶；以浓度依赖性方式降低YCU-T892、KCC-TC873、KB、HSC-4和YCU-T891细胞的活力；在250ng/ml时诱导HSC-4细胞在G1期细胞周期停滞；在300ng/ml时诱导Ms-1细胞凋亡。A bacterial metabolite with anticancer activity; an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50 = 0.02 µg/ml); selective for CDP-diacylglycerol:inositol 3-phosphatidyltransferase over PLC and phosphatidylinositol kinase at 10 µg/ml; decreases viability of YCU-T892, KCC-TC873, KB, HSC-4, and YCU-T891 cells in a concentration-dependent manner; induces cell cycle arrest in the G1 phase in HSC-4 cells at 250 ng/ml; induces apoptosis in Ms-1 cells at 300 ng/ml.