Phospho-PDE4D PKA site Positiv

Phosphorylation Control of Nuclear Receptors

modifications such as phosphorylations. During the last decade, knowledge of NRs phosphorylation advanced considerably because of the emergence of new technologies. Indeed, the development of a wide range of phosphorylation site databases, high accuracy mass

打破传统认知，降糖不仅依赖胰岛素！科学家发现，这种来自脂肪的激素也可以调节血糖……

加州萨尔克生物研究所的研究团队在 Cell Metabolism 发表了题为 FGF1 and insulin control lipolysis by convergent pathways 的研究性文章，他们发现，FGF1 可以像胰岛素一样，通过抑制脂肪分解来控制血糖，但这两种激素的作用方式是不同的。FGF1 抑制脂肪分解是通过脂肪组织中 PDE4D 的激活介导的，同时 FGF1 的抗脂解活性对于急性降糖也是必需的。 图片来源：Cell Metabolism 主要研究内容 FGF1 以一种依赖

A chemokine-driven positive feedback loop organizes lymphoid follicles

, establishing a positive feedback loop that is likely to be important in follicle development and homeostasis. In germinal centres the feedback loop is overridden, with B-cell lymphotoxin 1 2 expression being induced by a mechanism