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文献和实验Measurement of Phosphoinositide 3-Kinase Activity
only PtdIns as a substrate (e.g., mammalian PtdIns 3-kinase and yeast Vps34p) ( 1 ). Generally, PI 3 kinases are now regarded as an important intracellular signal upstream of a variety of biochemical (e.g., activation of Akt/protein kinase B and/or p70
Chemokine control of HIV-1 infection
underlying viral entry and tropism 4 . The virus strains responsible for transmission, which are the predominant virus type isolated from asymptomatic HIV-positive individuals, use CCR5 as a receptor, whereas viruses that emerge later in the course
Cell Cycle Checkpoint Control Mechanisms That Can Be Disrupted in Cancer
. Multiple checkpoints exist and are conserved in the cell cycle in higher eukaryotes to ensure that if one fails, others will take care of genomic integrity and cell survival. Many genes act as either positive or negative regulators of checkpoint function
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