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文献和实验Analysis of Molecular Species of Cellular Sphingomyelins and Ceramides
Ceramides (CER) have been proposed to be the intracellular mediators of responses to such agents as interferon-γ (IFN-γ), dexamethasone, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β, and vitamin D 3 . These agents induce hydrolysis
Characterization of Dopamine Receptors
Burris, K.D., Filtz, T.M., Chumpradit, S., Kung, M.P., Foulon, C., Hensler, J.G., Kung, H.F., and Molinoff, P.B. 1994. Characterization of [125I] (R)‐trans‐7‐hydroxy‐2‐[N‐propyl‐N‐(3‐iodo‐2′‐propenyl)amino]tetralin binding to dopamine D3 receptors in rat
Overview of Receptor Allosterism
ligand efficacy. The lower panels simulate the effect of a positive allosteric modulator of affinity (α = 10), which is either a positive (D and F ; β = 3) or negative (E ; β = 0.3) modulator of orthosteric ligand efficacy. Panels C and F illustrate
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