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- 2025年07月08日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
- 保质期：
12个月
- 库存：
999
- 供应商：
武汉伊莱瑞特生物科技股份有限公司
- 抗体英文名：
APC Anti-Human CD11b Antibody[HI11b]
- 规格：
100Tests/20Tests/100Tests×2
| 规格： | 100Tests | 产品价格： | ￥1296.0 |
|---|---|---|---|
| 规格： | 20Tests | 产品价格： | ￥360.0 |
| 规格： | 100Tests×2 | 产品价格： | ￥2160.0 |
产品名称：APC Anti-Human CD11b Antibody[HI11b]
货号：E-AB-F1317E
| Background |
CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αMintegrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2(CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and factor X.
|
| Swissprot |
P11215
|
| Gene ID |
3684
|
| Clone No |
HI11b
|
| Host |
Mouse
|
| Reactivity |
Human
|
| Application |
FCM
|
| Isotype |
Mouse IgG2b, κ
|
| Isotype Control |
APC Mouse IgG2b, κ Isotype Control[MPC-11]
|
| Conjugation |
APC
|
| Conjugation Information |
APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter).
|
| Spectrum |
|
| Storage Buffer |
Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.
|
| Storage |
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
|
| Expiration date |
12个月
|
| Shipping |
冰袋
|
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文献和实验（Antigen-presenting Cells, APC）。粒细胞主要分为三种：中性粒细胞、嗜酸性粒细胞和嗜碱性粒细胞。其中，中性粒细胞在哺乳动物血液白细胞中所占比例最大，而嗜酸性粒细胞和嗜碱性粒细胞数量稀少，均不超过白细胞数量的 1%，在免疫学研究中的关注相对较少。 血液中的单核细胞对机体发生的损伤和炎症响应迅速，通常在 8~12 小时就能进入病灶部位。小鼠血液中，单核细胞以典型的 CD11b（Cat#E-AB-F1081）和 CD115（Cat#E-AB-F1107）双阳特征出现，而在人的外周血中
Stimulation of Anti-HIV-1 Cytotoxic T Lymphocytes by Dendritic Cells
Dendritic cells (DC) are highly specialized antigen-presenting cells (APC) in both primary and secondary T-cell responses. This may be related to their expression of high levels of MHC class I and II antigens (1 -4 ), costimulatory
如何返老还童，逆转大脑衰老？肠道菌群和大脑的奇妙关联又双叒叕
细胞活化紧密相关，并对微生物组变化敏感的 CD103+ 树突细胞有所减少；MLN 中 F4/80+ 巨噬细胞的比例下降，而 Ly6chi 单核细胞中 CD11b 的表达则得到了恢复。尽管衰老过程对循环系统中先天免疫和适应性免疫有很强的影响，但粪便移植能够有效缓解 Ly6G+ 中性粒细胞中 CD11b 表达的上升，并且能够抑制衰老引发的外周白细胞介素 (IL)-10 的升高。然而，粪便移植并没有逆转衰老引起的 IFN-γ 和 IL-5 的减少。这表明粪便移植能够选择性地调节老年小鼠的外周以及 MLN 免疫
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