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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
peptide
- 亚型:
IgG1
- 形态:
Liquid
- 保存条件:
-20℃
- 克隆性:
mAb
- 适应物种:
Human
- 保质期:
1年
- 目录编号:
TD-31457
- 级别:
科研级
- 库存:
88
- 供应商:
武汉天德
- 宿主:
Mouse
- 应用范围:
FCM、ELISA、IHC、WB
- 靶点:
详询
- 抗体英文名:
Mouse Monoclonal Antibody to CD42B
- 抗体名:
CD42B
- 规格:
100ul/50ul
| 规格: | 100ul | 产品价格: | ¥2180.0 |
|---|---|---|---|
| 规格: | 50ul | 产品价格: | ¥1280.0 |
Mouse Monoclonal Antibody to CD42B
Description |
|
| Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. | |
Specification |
|
| Aliases | GP1BA; BSS; GP1B; VWDP; GPIbA; BDPLT1; BDPLT3; DBPLT3; GPIbalpha; CD42b-alpha |
| Entrez GeneID | 2811 |
| Swissprot | P07359 |
| clone | 6H6H10 |
| WB Predicted band size | 71.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD42B (AA: extra 17-183) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
|
| WB | 1/500 - 1/2000 |
| IHC | 1/200 - 1/1000 |
| FCM | 1/200 - 1/400 |
| ELISA | 1/10000 |
Product Image |
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文献和实验CD42a/CD42b/CD42c/CD42d 分子 CD42a 常用单克隆抗体或代号: FMC25,GR- P;(GPIX) 主要表达细胞: Pt,Meg [Pt] 分子质量(kDa)和结构: gp22,形成血小板,GPIb/Ⅸ复合物功 能: 血小板粘附,结合vWF、凝血酶 CD42b 常用单克隆抗体或代号: PHN89,AN51;(GPIba ) 主要表达细胞: Pt,Meg [Pt]
人血小板膜糖蛋白ⅠbⅨα(GP-ⅠbⅨα/CD42b+CD42a)抗体
人血小板膜糖蛋白Ⅰb Ⅸα(GP- Ⅰb Ⅸα/CD42b+CD42a )抗体 酶联免疫分析试剂盒使用说明书 本试剂仅供研究使用 目的:本试剂盒用于测定人血清,血浆及相关液体样本中血小板膜糖蛋白Ⅰb Ⅸα(GP- Ⅰb Ⅸα/CD42b+CD42a )抗体 的含量。 实验原理: 本试剂盒应用双抗原夹心法测定标本中人血小板膜糖蛋白Ⅰ b Ⅸα( GP- Ⅰ b Ⅸα /CD42b+CD42a )抗体
体颗粒表面有 CD63 抗原。血小板活化时,由于颗粒膜蛋白与血小板膜蛋白相互融合,使颗粒膜蛋白翻转到血小板膜表面。因此,可通过检测这些颗粒膜蛋白来判断血小板的活化状态。 3. 采血 EDTA 抗凝采血,取后段血。因前段血中可能有组织液存在,造成人为血小板活化。 4. 试剂选择 FITC 标记的 CD42b 抗体 PE 标记的 CD62p 或 CD63 抗体 在血小板膜表面稳定表达的抗原有 CD
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