- ￥1680 - 2680
- Tanda
- 中国
- TD-500218
- 2025年11月04日
- WB,IHC-P,ICC/IF
- Rabbit
- Human,Mouse,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant protein of human CD40
- 亚型：
IgG
- 形态：
Liquid
- 保存条件：
-20℃
- 克隆性：
pAb
- 适应物种：
Human,Mouse,Rat
- 保质期：
1年
- 目录编号：
TD-500218
- 级别：
科研级
- 库存：
88
- 供应商：
武汉天德
- 宿主：
Rabbit
- 应用范围：
WB,IHC-P,ICC/IF
- 靶点：
详询
- 抗体英文名：
CD40
- 抗体名：
CD40
- 规格：
100ul/50ul
| 规格： | 100ul | 产品价格： | ￥2680.0 |
|---|---|---|---|
| 规格： | 50ul | 产品价格： | ￥1680.0 |
产品详情
|
Product Name
|
CD40 Rabbit pAb
|
|
Gene ID
|
958
|
|
SwissProt ID
|
P25942
|
|
Gene Name
|
CD40
|
|
Alternative Names
|
CD40; TNFRSF5; Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD antigen CD40
|
|
Background
|
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
|
|
Research Field
|
Immunology
|
|
Product Categories
|
Primary antibody
|
|
Host
|
Rabbit
|
|
Reactivity
|
Human,Mouse,Rat
|
|
Application
|
WB,IHC-P,ICC/IF
|
|
Dilution Ratio
|
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
|
|
Molecular Weight
|
Calculated MW: 31 kDa; Ob/served MW: 45 kDa
|
|
Clonality
|
Polyclonal Antibody
|
|
Clonality No.
|
-
|
|
Isotype
|
IgG
|
|
Immunogen
|
Recombinant protein of human CD40
|
|
Purification
|
Affinity Purified
|
|
Conjugation
|
Unconjugated
|
|
Modification
|
Unmodified
|
|
Form
|
Liquid
|
|
Buffer System
|
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
|
|
Storage
|
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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文献和实验CD40 分子 CD40 常用单克隆抗体或代号： G28- 5,EA- 5 主要表达细胞： B,M,FDC,并指细胞,上皮 [B] 分子质量(kDa)和结构： gp50(TNFR- SF) 功 能： B细胞生长、分化和记忆细胞产生,配体为CD40L,T- B相互作用 CD40 Plays a central role in regulating cell-mediated
0:00 人CD40活化B细胞的分离0 0:14 内容简介14 1:46 制备饲养细胞106 2:27 制备CD40刺激用的外周血单个核细胞（PBMC）147 4:38 制备饲养细胞278 8:33 CD40刺激作用513 9:50 转种590 12:20 分析CD40活化B细胞740 12:55 结论775 人CD40活化B细胞的分离本视频来源于网络，如有异议请联系我们，我们将在5个工作日内作出处理。
白细胞分化抗原及其功能 CD40L 即CDl54分子，属于TNFSF成员，为Ⅱ型膜蛋白。 人CD40L主要表达在活化的CD4+T细胞以及部分CD8+T细胞和YaT细胞。此外，CD40L还表达于活化的嗜碱粒细胞、肥大细胞、NK细胞、某些单核细胞以及活化B细胞。静止淋巴细胞不表达CD40L。CD40L往往以三聚体形式结合三聚体的CD40分子(TNFR超家族成员)发挥生物学作用，即传递B细胞活化的第二信号(见第九章)。缺少第二
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