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- Biorbyt
- 英国
- orb2279094
- 2026年08月07日
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- 文献和实验
- 技术资料
- 保存条件：
详询
- 保质期：
12 months from date of receipt.
- 英文名：
Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Br
- 库存：
99
- 供应商：
Biorbyt
- CAS号：
2344809-82-9
- 规格：
5 mg/50 mg
| 规格： | 5 mg | 产品价格： | ￥0.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥0.0 |
描述: Glucocorticoid Receptor Agonist-1 Phosphate (Gly-Glu-Br) is a phosphate-containing linker-payload used in the construction of antibody-drug conjugates (ADCs) such as ABBV-154. It is applied in oncology research for developing targeted therapeutics, with its utility demonstrated in preclinical in vitro and in vivo studies for selective drug delivery.
靶点: Drug-Linker Conjugates for ADC
分子式: C44H51BrN3O14P
分子量: 956.77
SMILES: C(COP(=O)(O)O)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(O[C@H](O2)C4=CC=C(CC5=CC(NC([C@@H](NC(CNC(CBr)=O)=O)CCC(O)=O)=O)=CC=C5)C=C4)[H])([C@]6([C@]([C@@H](O)C3)([C@]7(C)C(CC6)=CC(=O)C=C7)[H])[H])[H]
研究领域: Pharmacology & Drug Discovery
保存条件: -20°C
备注: For research use only.
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文献和实验(HY-164893) www.medchemexpress.cn/abbv-154.html ADC Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Br (HY-137883) www.medchemexpress.cn/glucocorticoid-receptor-agonist-1-phosphate-gly-glu-br.html Drug-Linker Conjugates
. These include receptormediated GDP release, GTP binding, and GTP hydrolysis. Fig. 1. Schematic diagram of receptor-mediated activation/mactivation cycle of G protein ( see Introduction for detailed comments). A, agonist; R
Characterization of Nuclear Receptor Ligands by Multiplexed Peptide Interactions
, although described for nuclear receptors, may also be applied to other types of molecular interactions. Keywords: Microsphere; flow cytometry; nuclear receptor; coactivator; corepressor; cofactor; agonist; antagonist; ligand; ligand binding
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