- ￥3627
- Biorbyt
- 英国
- orb2279059
- 2026年08月07日
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- 文献和实验
- 技术资料
- 保存条件：
详询
- 保质期：
12 months from date of receipt.
- 英文名：
MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide-Exatecan
- 库存：
99
- 供应商：
Biorbyt
- CAS号：
2414254-41-2
- 规格：
1 mg
描述: This research compound is an antibody-drug conjugate (ADC) featuring the exatecan derivative MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide. It is utilized in oncology research to investigate targeted drug delivery, with applications in both in vitro cytotoxicity assays and in vivo efficacy studies for tumor models.
靶点: Topoisomerase,Drug-Linker Conjugates for ADC
分子式: C54H58FN9O13
分子量: 1060.09
SMILES: N(C(=O)C1(OCNC(CNC([C@H](CC2=CC=CC=C2)NC(CNC(CNC(CCCCCN3C(=O)C=CC3=O)=O)=O)=O)=O)=O)CC1)[C@@H]4C5=C6C(C=7N(C6)C(=O)C8=C(C7)[C@](CC)(O)C(=O)OC8)=NC=9C5=C(CC4)C(C)=C(F)C9
研究领域: Molecular Biology, Pharmacology & Drug Discovery
保存条件: -20°C
备注: For research use only.
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文献和实验Mc-Val-Ala-PAB (HY-126364) www.medchemexpress.cn/mc-val-ala-pab.html ADC Protease Cleavable Linker Mc-Gly-Gly-Phe-Gly-PAB-OH (HY-136432) www.medchemexpress.cn/mc-gly-gly-phe-gly-pab-oh.html ADC Protease Cleavable Linker
ring (1 ) and one series with a methylene group inserted between the ring and the carboxylic acid group (7 ). Since we have focused on the design and synthesis of Phe-Gly mimetics, the synthetic examples described here start from l -phenylalanine
F Phe - Phenylalanine R Arg - Arginine G Gly - Glycine S Ser - Serine H His - Histidine T Thr - Threonine
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