- ￥0
- Biorbyt
- 英国
- orb2278121
- 2026年08月07日
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- 文献和实验
- 技术资料
- 保存条件：
详询
- 保质期：
12 months from date of receipt.
- 英文名：
Mcl-1 inhibitor 15
- 库存：
99
- 供应商：
Biorbyt
- 规格：
5 mg/50 mg
| 规格： | 5 mg | 产品价格： | ￥0.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥0.0 |
描述: Mcl-1 Inhibitor 15 (Compound (Ra)-15) is a potent small molecule with a Ki of 0.02 nM, designed for cancer research. It is applied in vitro and in vivo to study apoptosis and tumor biology, particularly in hematological malignancies, by selectively inhibiting the Mcl-1 protein.
靶点: Others,Bcl-2 Family
分子式: C40H42ClFN6O4S
分子量: 757.32
研究领域: Cell Biology, Pharmacology & Drug Discovery; Cell Biology
保存条件: -20°C
备注: For research use only.
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文献和实验Differential Expression of Apoptosis-Associated Genes bax and bcl-2 in Ovarian Cancer
either as inhibitors (e.g., bcl-2, bcl-xl, mcl- 1) or promoters (e.g., bcl-xs, bax, bak, bad) of apoptosis (1 -3 ). The chromosomal translocation t(14;18), leading to overexpression of the Bcl-2 protein was first described in human B-cell lymphoma (4 ). Later
) and endonuclease-G (endo-G), from the mitochondria into the cytosol through a process that can be blocked by anti-apoptotic multi-domain Bcl-2 family members (Bcl-2, Bcl-xL, Bcl-w, Mcl-1, A1/Bfl1 and Bcl-B). Cytochrome c release is essential
[资源] 所有的看家基因(housekeeping genes)列表+引物设计服务
2-related) (MCL1), mRNA 961 NM_021959 Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 11 (PPP1R11), mRNA 462 NM_014730 Homo sapiens KIAA0152 gene product (KIAA0152), mRNA 713 NM_014402 Homo sapiens low molecular mass ubiquinone
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