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- Biorbyt
- 英国
- orb2277659
- 2026年08月07日
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- 文献和实验
- 技术资料
- 保存条件：
详询
- 保质期：
12 months from date of receipt.
- 英文名：
Raf inhibitor 3
- 库存：
99
- 供应商：
Biorbyt
- CAS号：
1662682-11-2
- 规格：
5 mg/50 mg
| 规格： | 5 mg | 产品价格： | ￥0.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥0.0 |
描述: Example 30, known as Raf inhibitor 3, is a potent dual inhibitor of B-Raf and C-Raf with IC50 values under 15 nM. This compound is a valuable tool in cancer research, applicable for both in vitro biochemical assays and in vivo studies investigating oncogenic RAF signaling pathways.
靶点: Raf
分子式: C18H19FN8O2S
分子量: 430.46
SMILES: FC1=C(C=2C(=NN(C(C)C)N2)C=3C=NNC3)C=CC=C1NS(=O)(=O)C4=CN(C)N=C4
研究领域: Neuroscience; Pharmacology & Drug Discovery, Signal Transduction
保存条件: -20°C
备注: For research use only.
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文献和实验MAP Kinase Regulation of the Mitotic Spindle Checkpoint
. We demonstrated that the mitogen-activated protein kinase (MAPK) cascade regulates mitotic progression and the spindle checkpoint. As demonstrated by immunofluorescence at kinetochores, depletion of Raf Kinase Inhibitory Protein (RKIP), an inhibitor of Raf/MEK/ERK
The Regulation of Tumor Suppressor Genes by Oncogenes
Tumor suppressor genes (TSGs) and oncogenes represent the ying and the yang of cell growth, differentiation, and survival control. TSGs such as p53, the retinoblastoma (RB) gene product, and the cyclin kinase inhibitor (CKI) proteins p21 Cip
14-3-3 is a potent inhibitor of protein kinase C, but the N-terminal domain does not inhibit PKC activity. Site-specific mutagenesis of several regions in the tau isoform of 14-3-3, including the mutation of a putative pseudosubstrate site
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