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4-Amino-1-[3,5-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-beta-D-ribofuranosyl]-1,3,5-triazin-2(1H)-one,orb1908101,Biorbyt
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
详询
- 保质期:
6-12个月
- 英文名:
CpG ODN 10101
- 库存:
99
- 供应商:
Biorbyt
- CAS号:
1234402-77-7
- 规格:
1 mg
产品名:CpG ODN 10101
货号:orb1982537
产品中文名:CpG ODN 10101
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文献和实验Adjuvant Properties of CpG Oligonucleotides in Primates
indicate that CpG oligonucleotides (ODN) are well tolerated and improve the immune response to microbial vaccines. This work examines the progress in utilizing CpG ODN as adjuvants in conventional and DNA vaccines.
Immunostimulatory CpG Motifs and DNA Vaccines
can also be obtained with synthetic oligonucleotides (ODN) (6 ,7 ) or plasmid DNA vectors (8 ) containing CpG immunostimulatory motifs. From a teleological view, it appears likely that the rapid immune activation in response to CpG DNA may have evolved
免疫刺激序列基因佐剂 免疫刺激序列(ISS)为非甲基化的短核苷酸(胞嘧啶和鸟嘌呤,CpG)为基序的寡脱氧核苷酸(ODN)短序列,其序列中的5’-嘌呤-嘌呤-CpG-嘧啶-嘧啶-3’对人和动物有强烈的免疫刺激作用,可以诱导以Thl为主的免疫应答,诱导产生Thl类细胞因子如IL-1、IL-6、IL-12、IL-18、TNF等,增加免疫相关细胞MHC-Ⅱ类分子、CD40、B7-2、ICAM、CMF等表达,增强炎性细胞因子的分泌,促进抗原呈递细胞的分化和成熟,增强
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