产品封面图
文献支持

Cynomolgus PD-L1(CA94)

收藏
  • ¥720 - 14400
  • SinoBio
  • 国产
  • CA94
  • 2025年10月28日
    avatar
  • 企业认证

    点击 QQ 联系

  • 万千商家帮你免费找货

    0 人在求购买到急需产品
    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      蛋白表达区间:Phe19-Thr239

    • 保质期

      See instructions

    • 英文名

      标签:C-Fc

    • 库存

      表达系统:Human Cells

    • 供应商

      上海经科化学科技有限公司

    • 规格

      10ug/50ug/500ug/1mg

    规格:10ug产品价格:¥720.0
    规格:50ug产品价格:¥2000.0
    规格:500ug产品价格:¥10080.0
    规格:1mg产品价格:¥14400.0
    产品描述
    Recombinant Cynomolgus CD274 Molecule is produced by our Mammalian expression system and the target gene encoding Phe19-Thr239 is expressed with a human IgG1 Fc tag at the C-terminus.
    蛋白编号
    G7PSE7
    产品别称
    B7-H; B7H1; B7-H1; B7H1PDCD1L1; CD274 antigenMGC142294; CD274 molecule; CD274; PDCD1L1; PDCD1LG1; PDL1; PD-L1; PD-L1B7 homolog 1; PDL1PDCD1 ligand 1; programmed cell death 1 ligand 1; Programmed death ligand 1
    偶联
    Unconjugated
    分子量
    52.4 KDa
    表观分子量
    73 KDa, reducing conditions
    剂型描述
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    内毒素
    < 1 EU/µg as determined by LAL test.
    纯度-SDS-PAGE
    Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
    生物活性-BLI
    Loaded Biotinylated Human PD-1-His-Avi(Cat#CY18) on SA Biosensor, can bind Cynomolgus PD-L1-Fc (Cat#CA94) with an affinity constant of 14.1 nM as determined in BLI assay. (Regularly tested)
    生物活性-ELISA
    Immobilized Cynomolgus PD-L1-Fc(Cat#CA94) at 2μg/ml (100 μl/well) can bind Anti-Human PDL1 mAb(Cat#NC014).The ED50 of Anti-Human PDL1 mAb(Cat#NC014) is 8.15 ng/ml. (Regularly tested)
    复溶
    • Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
    • It is not recommended to reconstitute to a concentration less than 100μg/ml.
    • Dissolve the lyophilized protein in distilled water.
    • Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
    运输条件
    • The product is shipped at ambient temperature.
    • Upon receipt, store it immediately at the temperature listed below.
    保存条件
    • Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
    • Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
    • Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
    产品背景
    CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

    风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。

    图标文献和实验
    该产品被引用文献

    CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

    相关实验
    • 中科院高福院士课题组 2020 年发表了哪些重要的研究成果?

      抗体 523-11 形成复合物。RABV-G 具有三个结构域,碱性至酸性 pH 值变化会导致较大的结构域重新定向和伴随的结构域 - 接头重建,从而将其从弯曲的发夹构型转变为延伸的构型。在这种低 pH 诱导的结构转变过程中,发现位于域连接子中的残基在糖蛋白介导的膜融合中起重要作用。最后,该抗体主要通过其重链与 RABV-G 相互作用,并与病毒蛋白中的二聚体构象表位结合以进行中和。这些结构为疫苗和药物设计提供了有价值的信息。 图源:Cell Host & Microbe 3、发现,PD-1、PD-L1 普遍

    • 抗癌药物的自述

      %。我的天敌很可怕,但是我也不是吃素的。Statista 2016年的一份统计报告预测了2020年全球十大抗癌药。看到没,这些都是我家族成员。 数据来源于www.statista.com 由于我家族成员众多,对付敌人的方式各不相同。我就给大家选择性的介绍一下吧。PD-1/PD-L1最近比较有名气,市场对它激烈程度无法想象,其市场峰值高达350亿美元。默沙东(Merck)、百时美施贵宝(BMS)、阿斯利康(AZN)、罗氏(Roche)均在火速推进各自的临床项目。唉呀妈呀

    • 文献速递:个性化循环肿瘤 DNA 可成为免疫治疗疗效新型biomarker

      研究背景 使用程序性死亡-1抑制剂或其配体(抗PD-1/PD-L1)的免疫检查点阻断 (ICB) 疗法已成为治疗许多癌症的有效方法。然而仅有少数患者对ICB疗法表现出长期良好的反应,大多数患者对免疫检查点阻断剂都没有阳性反应或因为阻断剂的不良反应而不得不停止服用。虽然已经发现了许多类别的生物标志物,但目前仍未发现强有力的治疗反应预测标志物。寻求新的ICB反应的非侵入性生物标志物能大大提高ICB疗法的临床效果。 研究内容及结果 2020年9月,在Nature子刊Nature Cancer

    同类产品报价

    产品名称
    产品价格
    公司名称
    报价日期
    ¥720
    上海经科化学科技有限公司
    2025年12月22日询价
    ¥2600
    杭州斯达特生物科技有限公司
    2025年12月23日询价
    ¥11424
    武汉博欧特生物科技有限公司
    2025年07月09日询价
    ¥720
    苏州近岸蛋白质科技股份有限公司
    2025年10月16日询价
    文献支持
    Cynomolgus PD-L1(CA94)
    ¥720 - 14400