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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
蛋白表达区间:Cys89-Phe760
- 保质期：
See instructions
- 英文名：
标签:N-6His
- 库存：
表达系统:Human Cells
- 供应商：
上海经科化学科技有限公司
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ￥840.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥2520.0 |
| 规格： | 500ug | 产品价格： | ￥12320.0 |
| 规格： | 1mg | 产品价格： | ￥17600.0 |
- Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
- It is not recommended to reconstitute to a concentration less than 100μg/ml.
- Dissolve the lyophilized protein in distilled water.
- Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- The product is shipped at ambient temperature.
- Upon receipt, store it immediately at the temperature listed below.
- Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
- Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
- Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
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文献和实验Transferrin receptor protein 1 (TFRC) belongs to the peptidase M28 family that is synthesized as a 172 amino acid (aa). TFRC regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. It binds one transferrin or HFE molecule per subunit and binds the HLA class II histocompatibility antigen, DR1. It Interacts with SH3BP3 and STEAP3, facilitates TFRC endocytosis in erythroid precursor cells. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. It positively regulates T and B cell proliferation through iron uptake.
间日疟原虫和DARC表面也存在成熟的红细胞,然而这些都不是由间日疟原虫入侵。另外的受体/配体相互作用也被认为与此有关。正如它们的名字所暗示的，间日疟原虫网织红细胞结合蛋白家族(PvRBP)也被证明参与了分殖子与网织红细胞的结合，但它们结合的受体直到最近才被确定。鉴定一个额外的受体/配体系统转铁蛋白受体1 (TfR1)是一种表面蛋白，作为铁载体转铁蛋白的受体参与血红细胞的铁吸收。它存在于网织细胞的表面，但随着网织细胞的成熟而消失。间日疟原虫优先侵入表达高水平这种受体的网织细胞。网织
红细胞DARC-negative一些人感染间日疟原虫和DARC表面也存在成熟的红细胞,然而这些都不是由间日疟原虫入侵。额外的受体/配体相互作用被认为是参与。正如它们的名字所暗示的，一种被称为间日疟原虫网状细胞结合蛋白家族(PvRBP)的蛋白质也被证明参与了分生子与网状细胞的结合，但直到最近才发现它们结合的受体。额外受体/配体系统的识别转铁蛋白受体1 (Transferrin receptor 1, TfR1)是一种表面蛋白，作为铁负荷转铁蛋白的受体，参与铁在红细胞中的摄取。它存在于网状细胞表面，但在成熟时
Embryo fetal Development Studies in Nonhuman Primates
Embryo fetal development (EFD) studies in nonhuman primates are frequently conducted in macaques with Macaca fascicularis (cynomolgus monkey, long-tailed macaque, crab-eating macaque) being the most accepted model. EFD studies
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