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- cyt-1135
- 2025年12月28日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
for future use below -18°C
- 保质期：
See instructions
- 英文名：
mTSLP
- 库存：
常规产品有备货
- 供应商：
上海经科化学科技有限公司
- CAS号：
无
- 规格：
1ug/5ug/50ug
| 规格： | 1ug | 产品价格： | ￥1080.0 |
|---|---|---|---|
| 规格： | 5ug | 产品价格： | ￥2415.0 |
| 规格： | 50ug | 产品价格： | ￥20286.0 |
CATALOGUE NUMBER
CYT-1135
SYNONYMS
Thymic Stromal Lymphopoietin, TSLP.
INTRODUCTION
TSLP protein is a hemopoietic cytokine which signals throughout a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor & the Interleukin-7 receptor alpha chain. TSLP impacts myeloid cells thus induces the discharge of T cell-attracting chemokines from monocytes & increases the growth of CD11c(+) dendritic cells. TSLP is mainly expressed in the heart, liver and prostate. TSLP is related in its biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the Interleukin-7 receptor alpha chain & the TSLPR. Similar to IL-7, TSLP enhances phosphorylation of STAT3 and STAT5, though uses kinases excluding JAKs for its activation. TSLP induces the release of T cell-attracting chemokines such asTARC & MDC from monocytes & triggers CD11c(+) dendritic cells. TSLP activated dendritic cells primes naive T cells to manufacture pro-allergic cytokines such as Iinterleukin-4, Interleukin-5, Interleukin-13 and TNF-alpha whereas down-regulating Interleukin-10 and IFN-gamma play a role in the initiation of allergic inflammation.
DESCRIPTION
TSLP Mouse Recombinant produced in Baculovirus is a single glycosylated polypeptide chain containing 130 amino acids (20-140aa) and having a molecular mass of 15.0kDa.
TSLP is fused to a 29 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
SOURCE
Sf9, Baculovirus cells.
PHYSICAL APPEARANCE
FORMULATION
The TSLP solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
STABILITY
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
PURITY
Greater than 90.0% as determined by SDS-PAGE.
AMINO ACID SEQUENCE
ADPYNFSNCN FTSITKIYCN IIFHDLTGDL KGAKFEQIED CESKPACLLK IEYYTLNPIP
GCPSLPDKTF ARRTREALND HCPGYPETER NDGTQEMAQE VQNICLNQTS QILRLWYSFM QSPEHHHHHH
SAFETY DATA SHEET
SDS
USAGE
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文献和实验TSLP Mouse Recombinant produced in Baculovirus is a single glycosylated polypeptide chain containing 130 amino acids (20-140aa) and having a molecular mass of 15.0kDa.
TSLP is fused to a 29 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
Retroviral Transduction in Fetal Thymic Organ Culture
T-cell development requires cytokines and intimate contact with stromal cells provided exclusively by the thymus. Consequently, an in vitro model of thymocyte differentiation, fetal thymic organ culture (FTOC), has been developed. FTOC
以「出汗」的方式排出脂肪！Science 揭示这种细胞因子或
米色化从而提高代谢率；此外，免疫抑制性细胞 Treg 则可通过促进胰岛素敏感性而预防 II 型糖尿病。胸腺基质淋巴细胞生成素 (Thymic stromal lymphopoietin, TSLP) 是一种上皮细胞来源的细胞因子，也是一种免疫系统蛋白，参与哮喘和其他过敏性疾病，在皮肤、肠道等屏障部位表达，也已被证明可以作为 2 型免疫细胞的激活剂，并可以显著增加 Treg。结合先前的研究，即免疫细胞调节脂肪代谢，研究人员推测：是否可以通过 TSLP 调节特定免疫细胞而发挥对抗肥胖及其相关并发
Intrathymic Delivery of MHC Genes Using Recombinant Adenoviruses
system to deliver MHC class II genes to the thymic stroma. When injected into MHC class II-deficient animals (IIo ) (4 ), these vectors punctually restore the expression of MHC class II molecules on the surface of transduced thymic stromal cells (5 ). In turn
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