m-dPEG ®-NHS ester-100 mg-m-dP

m-dPEG ®-NHS ester-100 mg，m-dPEG®₃₇-NHS ester-100 mg，m-dPEG ®-NHS ester-100 mg,m-dPEG®₃₇-NHS ester-100 mg

m-dPEG ®-NHS ester-100 mg-m-dPEG®₃₇-NHS ester-100 mg

产品货号：CCT-QBD-10910-100

产品规格：100mg

m-dPEG®37-NHS酯，产品编号QBD-10910，是一种长的(112个原子，133.9 μ m)甲基封端的离散长度聚乙二醇(dPEG®)间隔基，用N-羟基琥珀酰亚胺基(NHS)酯官能化以修饰具有可接近的游离胺的表面。游离胺在pH 7.0 - 7.5的水性介质中与NHS酯最佳反应。在水性介质中，酯水解成羧酸的速率随着pH的增加而增加。此外，应当注意，使生物分子(例如，蛋白质和肽)与该不带电荷的甲基封端的dPEG®间隔基的结合可以改变所得缀合物的总电荷。

m-dPEG®37-NHS ester, product number QBD-10910, is a long (112 atoms, 133.9 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer functionalized with an N-hydroxysuccinimidyl (NHS) ester to modify surfaces having accessible free amines.Free amines react optimally with NHS esters in aqueous media at pH 7.0 – 7.5. In aqueous media, the rate at which the ester hydrolyzes to the carboxylic acid increases with increasing pH. Moreover, it should be noted that reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.m-dPEG®37-NHS ester, product number QBD-10910, has been used successfully to modify silica shelled quantum dots used in imaging applications to make them water-soluble. Also, it has been employed to improve the pharmacokinetic (PK) and biodistribution (BD) properties of an antibody that targets an epitope that is found exclusively in adenocarcinomas. Carbon nanotubes and inorganic nanoparticles with amine-functionalized surfaces could also be modified to passivate the surface and make it hydrophilic. Moreover, proteins and other biomolecules conjugated to this product will have higher water solubility, reduced or eliminated antigenicity, reduced propensity to aggregate, and improved PK and BD properties.

m-dPEG ®-NHS ester-100 mg-m-dPEG®₃₇-NHS ester-100 mg

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