Bis-dPEG® β-生物素-1000 mg-Bis-dP

Bis-dPEG® β-生物素-1000 mg，Bis-dPEG®₃-biotin-1000 mg，Bis-dPEG® β-生物素-1000 mg,Bis-dPEG®₃-biotin-1000 mg

Bis-dPEG® β-生物素-1000 mg-Bis-dPEG®₃-biotin-1000 mg

产品货号：CCT-QBD-10325-1000

产品规格：1000mg

Bis-dPEG®3-biotin(产品编号QBD-10325)是一种新型生物素标记产品，由dPEG®3间隔区和连接在间隔区两端的生物素组成。Bis-dPEG®3-biotin可与两个不同的抗生物素蛋白/链霉亲和素结合位点(分子内和分子间)结合，为客户提供了利用生物素-抗生物素蛋白/链霉亲和素亲和素亲和力的独特机会。事实上，该产品专门用于阻断所有细胞和组织中发现的内源性生物素，因此在已知内源性生物素会引起问题的治疗和诊断应用中，它不会干扰靶向生物素-链霉亲和素相互作用。

Bis-dPEG®3-biotin, product number QBD-10325, is a novel biotin-labeling product composed of a dPEG®3 spacer with biotin attached to each end of the spacer, Bis-dPEG®3-biotin offers customers unique opportunities for exploiting the biotin-avidin/streptavidin affinity since it can bind to two different avidin/streptavidin binding sites, both intramolecularly and intermolecularly. Indeed, this product was developed specifically to block endogenous biotin found in all cells and tissues so that it did not interfere with targeted biotin-streptavidin interactions in therapeutic and diagnostic applications where endogenous biotin was known to cause problems.The binding behavior of Bis-dPEG®3-biotin with streptavidin opens up possible uses for the product in the self-assembly of supramolecular constructs and signal amplification. In the first example, if two parts of a potential supramolecular construct both contain avidin or streptavidin, addition of QBD-10325 under empirically determined optimized conditions could trigger self-assembly of the construct as the bis-dPEG®3-biotin binds to the separate avidin or streptavidin molecules in the two halves of the construct. In the second example, multiple streptavidin molecules conjugated to horseradish peroxidase (HRP) could be bound together with a streptavidin-biotinylated protein complex (for example, a biotinylated antibody), thus amplifying the signal from HRP.

Bis-dPEG® β-生物素-1000 mg-Bis-dPEG®₃-biotin-1000 mg

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