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文献和实验Basic Principles for the Study of Metastasis Using Animal Models
have become generally available. For more than 20 years, the mainstays of cancer research were a handful of transplanted rodent tumors. A few of these (most notably B16F10 and Lewis lung carcinoma) were used as metastasis models, generally by injecting the cells
Using In Vivo Biopanning for the Development of Radiation-Guided Drug Delivery Systems
with the ability to bind radiation-induced antigens, we inject the phage peptide library intravenously into mice bearing irradiated GL261 and Lewis lung carcinoma (LLC) hind limb tumors. Phage are recovered from excised tumors, amplified, and readministered
of cancer chemotherapeutic agents. Lewis lung carcinoma is a cell line established from the lung of a C57BL mouse bearing a tumor resulting from an implantation of primary Lewis lung carcinoma. The cells are reported to be highly tumorigenic, but weakly
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