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文献和实验synthetic protocol for a 2?selenothymidine phosphoramidite and its use in preparing Se?derivatized oligonucleotides are described here. The Se?modified phosphoramidite synthesis was achieved by activating a 2?thiothymidine derivative, followed
Synthesis of Building Blocks and Oligonucleotides with {G}O6‐Alkyl‐O6{G} Cross‐Links
? or a mono?phosphoramidite synthesis strategy can be employed. Both procedures require the preparation of a protected 2??deoxyguanosine?containing dimer where the two nucleosides are attached at the O6 ?atoms by an alkyl linker. This linker is introduced
Solid‐Phase Oligonucleotide Labeling with DOTA
a method to construct oligonucleotide conjugates labeled with 1,4,7,10?tetraazacyclododecane?1,4,7,10?tetraacetic acid (DOTA) on a solid support. A nucleosidic phosphoramidite that contains a protected DOTA ligand compatible with normal chain assembly
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