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Recombinant Human Wnt3a V3

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  • ￥1100
  • 近岸蛋白(Novoprotein)
  • C22R
  • 国产
  • 2026年04月27日
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    上海经科化学科技有限公司
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    • 库存：

      现货

    • 英文名：

      Recombinant Human Wnt3a V3

    • 保质期：

      6个月

    • 供应商：

      上海经科化学科技有限公司

    • 保存条件：

      -20℃

    • 规格：

      10ug

    产品描述
    Recombinant Human Wnt3a V3 is a Wnt Surrogate Protein and is produced by our Mammalian expression system.
     
    产品别称
    Wnt Surrogate-Fc Fusion Protein; Wnt Surrogate
     
    分子量
    58.5kDa
     
    表观分子量
    66-73kDa, reducing conditions.
     
    剂型描述
    Supplied as a 0.2 μm filtered solution of 25mM Tris-HCl, 500mM NaCl, pH8.2.
     
    内毒素
    < 0.01 EU/µg as determined by LAL test.
     
    纯度-SDS-PAGE
    产品细节图片1
    Greater than 95% as determined by reducing SDS-PAGE.
     
    生物活性-Cell Based Assay
    产品细节图片2Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells.The ED50 for this effect is 71.45 ng/ml.
    产品细节图片3Mouse Colon organoids were cultured with EGF (Cat#C029), Wnt3a (Cat#C22R), Noggin (Cat#C028) , and R-spondin 1 (Cat#CX83). The organoids showed good morphology.
    产品细节图片4Mouse Gastric organoids were cultured with EGF (Cat#C029), Wnt3a (Cat#C22R), Noggin (Cat#C028) , R-spondin 1 (Cat#CX83) and FGF-10 (Cat#CR11). The organoids showed good morphology.
    产品细节图片5Human intestinal organoids (ipsc source) were cultured with Activin A(Cat#C687) , BMP-4(CR93) , EGF (Cat#C029) , Wnt3a (Cat#C22R), Noggin (Cat#C028), R-spondin 1 (Cat#CX83) and FGF-4 (Cat#CR08) . The organoids showed good morphology.
    产品细节图片6Human breast cancer organoids were cultured with Wnt3a (Cat#C22R), Noggin (Cat#CB89) , R-spondin 3 (Cat#C18C) , KGF(Cat#CH73), FGF-10 (Cat#CR11), EGF (Cat#C029) and NRG1-beta 1 (Cat#753). The organoids showed good morphology.
     
    运输条件
    • The product is shipped on dry ice/polar packs.
    • Upon receipt, store it immediately at the temperature listed below.
     
    保存条件
    • Store at ≤-70°C, stable for 6 months after receipt.
    • Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
    • Please minimize freeze-thaw cycles.
     
    产品背景
    Wnt-3a is one of 19 vertebrate members of the Wingless-type MMTV integration site (Wnt) family of highly conserved cysteine-rich secreted glycoproteins important for normal developmental processes. WNT signaling plays key roles in the control of development, homeostasis, and regeneration of many essential organs and tissues, including bone, liver, skin, stomach, intestine, lung, kidney, central nervous system, mammary gland, taste bud, ovary, cochlea, and vessels among many others. Modulation of WNT signaling pathways has potential for treatment of degenerative diseases and tissue injuries. And they signal through FZD1-10 and LRP5 or 6, two families of receptors. Endogenous WNTs bind to multiple FZDs and are heavily modified posttranslationally, making them difficult to manufacture consistently. WNT surrogate molecules phenocopied endogenous ligand activities in in vitro reporter assays and intestine organoid functional assays. WNT surrogate molecules can be selective for individual FZD or a subfamily of FZDs in combination with LRP5 or LRP6, depending on the binder specificities.
     
    产品稳定性
    产品细节图片7Four independent lots were tested for activity and plotted on the same graph to show lot-to-lot consistency of Wnt3a V3. (Regularly tested)

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    图标文献和实验
    该产品被引用文献

    The protective effect of Wnt3a on inflammatory response in oxygen-glucose deprivation/reoxygenation (OGD/R) astrocyte model

    Su-Qin Chen, Ang Li, Min-Yan Feng, Wen-Qing Zhong, Liu Yang, Xiao-Yu Chen, Xing-Er Wu

    FOLIA NEUROPATHOLOGICA

     

    Cucurbitacin E Chemosensitizes Colorectal Cancer Cells via Mitigating TFAP4/Wnt/β-Catenin Signaling

    Peng Yang, Wen Liu, Rong Fu, Guo-bin Ding, Sajid Amin, Zhuoyu Li

    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

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