- ￥2223 - 19539
- Biorbyt
- 英国
- orb1819213
- 2026年08月07日
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- 文献和实验
- 技术资料
- 保存条件：
详询
- 保质期：
12 months from date of receipt.
- 英文名：
mTOR inhibitor 9d
- 库存：
99
- 供应商：
Biorbyt
- CAS号：
1144075-38-6
- 规格：
1 mg/5 mg/10 mg/25 mg/50 mg/100 mg/200 mg
| 规格： | 1 mg | 产品价格： | ￥2223.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥4563.0 |
| 规格： | 10 mg | 产品价格： | ￥6084.0 |
| 规格： | 25 mg | 产品价格： | ￥8307.0 |
| 规格： | 50 mg | 产品价格： | ￥10881.0 |
| 规格： | 100 mg | 产品价格： | ￥14742.0 |
| 规格： | 200 mg | 产品价格： | ￥19539.0 |
描述: The small molecule mTOR inhibitor 9d is a potent dual inhibitor of mTOR and PI3K kinases, exhibiting an mTOR IC50 of 0.31 nM. It is utilized in cancer research, including studies on leukemia and solid tumors, with applications in both in vitro cellular assays and in vivo xenograft models.
别名: mTOR, mTOR inhibitor 9d, 1(2hydroxyethyl)3{4[4(8oxa3azabicyclo[3.2.1]oct3yl)thieno[3,2d]pyrimidin2yl]phenyl}urea, PI3K
靶点: mTOR,PI3K
分子式: C21H23N5O3S
分子量: 425.5
纯度: 98.90% (May vary between batches)
SMILES: N(C(NCCO)=O)C1=CC=C(C2=NC(=C3C(=N2)C=CS3)N4CC5OC(C4)CC5)C=C1
溶解度: DMSO:45 mg/mL (105.76 mM)
研究领域: Pharmacology & Drug Discovery; Cell Biology, Signal Transduction
保存条件: -20°C
备注: For research use only.
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文献和实验The mammalian target of rapamycin (mTOR) is the catalytic subunit of two multiprotein complexes, mTOR complex-1 (mTORC1) and mTOR complex-2 (mTORC2). Clinically used rapamycin and rapalogs are FKBP12-dependent allosteric inhibitors of mTORC
Expanding Human T Regulatory Cells with the mTOR-Inhibitor Rapamycin
CD4+ CD25+ FOXP3+ T regulatory (Treg) cells are pivotal for the induction and maintenance of peripheral tolerance in both mice and humans. The possibility to use Treg cells for the treatment of T-cell-mediated diseases has recently gained
Development of ATP-Competitive mTOR Inhibitors
mTOR inhibitor rapamycin and structurally related rapalogs have failed to show significant single-agent antitumor efficacy in most types of cancer. This limited clinical success may be due to the inability of the rapalogs to maintain a complete blockade
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